Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1054485..1055711 Replicon chromosome
Accession NZ_CP102476
Organism Burkholderia cenocepacia strain NML110041

Toxin (Protein)


Gene name vapC Uniprot ID B4EFY1
Locus tag NUJ27_RS22500 Protein ID WP_006483155.1
Coordinates 1054485..1055066 (-) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NUJ27_RS22505 Protein ID WP_006483170.1
Coordinates 1055145..1055711 (-) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ27_RS22485 (NUJ27_22485) 1050188..1052233 - 2046 WP_006483164.1 MacB family efflux pump subunit -
NUJ27_RS22490 (NUJ27_22490) 1052236..1053429 - 1194 WP_006483156.1 efflux RND transporter periplasmic adaptor subunit -
NUJ27_RS22495 (NUJ27_22495) 1053701..1054429 - 729 WP_006483165.1 class I SAM-dependent methyltransferase -
NUJ27_RS22500 (NUJ27_22500) 1054485..1055066 - 582 WP_006483155.1 HD domain-containing protein Toxin
NUJ27_RS22505 (NUJ27_22505) 1055145..1055711 - 567 WP_006483170.1 helix-turn-helix transcriptional regulator Antitoxin
NUJ27_RS22510 (NUJ27_22510) 1056158..1057561 + 1404 WP_006483168.1 hypothetical protein -
NUJ27_RS22515 (NUJ27_22515) 1057655..1058227 + 573 WP_006483169.1 hypothetical protein -
NUJ27_RS22520 (NUJ27_22520) 1058306..1058695 - 390 WP_006483162.1 OsmC family protein -
NUJ27_RS22525 (NUJ27_22525) 1058926..1059657 + 732 WP_006483157.1 ribonuclease T2 -
NUJ27_RS22530 (NUJ27_22530) 1059683..1060318 - 636 WP_006483160.1 isochorismatase family cysteine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21324.94 Da        Isoelectric Point: 4.9629

>T253704 WP_006483155.1 NZ_CP102476:c1055066-1054485 [Burkholderia cenocepacia]
MNPDTIRARLDFLRDAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFAEALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSVHERDDLLTLTASLDRAARDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIREIVDVDTQRRIDAGGQRA

Download         Length: 582 bp

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 20583.56 Da        Isoelectric Point: 10.7753

>AT253704 WP_006483170.1 NZ_CP102476:c1055711-1055145 [Burkholderia cenocepacia]
MPHPPLHPSSLGPQLKRWRALHRVKQSHAAELFRVAQSTISRWEAGLQQMSPAERATAERLLAARLDSAGDHALARLIAG
STGRMHLVCDLTHRLLASSPARAAEFSRPLSTLLGASLWRYATPEIARMEAALDPLGWYDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAVRLVETLDAH

Download         Length: 567 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EFY1

Antitoxin

Source ID Structure

References