Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2245540..2246074 Replicon chromosome
Accession NZ_CP102475
Organism Burkholderia cenocepacia strain NML110041

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag NUJ27_RS10715 Protein ID WP_021033200.1
Coordinates 2245540..2245839 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag NUJ27_RS10720 Protein ID WP_021033199.1
Coordinates 2245829..2246074 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ27_RS10695 (NUJ27_10695) 2242381..2243130 + 750 WP_012492610.1 uroporphyrinogen-III C-methyltransferase -
NUJ27_RS10700 (NUJ27_10700) 2243127..2243504 + 378 WP_006496449.1 cobalamin biosynthesis protein -
NUJ27_RS10705 (NUJ27_10705) 2243540..2244142 + 603 WP_006476035.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
NUJ27_RS10710 (NUJ27_10710) 2244145..2245449 + 1305 WP_006486048.1 cobyrinate a,c-diamide synthase -
NUJ27_RS10715 (NUJ27_10715) 2245540..2245839 - 300 WP_021033200.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUJ27_RS10720 (NUJ27_10720) 2245829..2246074 - 246 WP_021033199.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
NUJ27_RS10725 (NUJ27_10725) 2246189..2247352 - 1164 WP_006486051.1 M20 aminoacylase family protein -
NUJ27_RS10730 (NUJ27_10730) 2247510..2248526 - 1017 WP_006492710.1 GNAT family N-acetyltransferase -
NUJ27_RS10735 (NUJ27_10735) 2248526..2249365 - 840 WP_006486043.1 malleobactin biosynthesis enzyme MbaF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11720.37 Da        Isoelectric Point: 6.9677

>T253703 WP_021033200.1 NZ_CP102475:c2245839-2245540 [Burkholderia cenocepacia]
MAVKGRQLRLTPLAECDLEDIWRYTAEHWSPEQAEHYYRDLIGTMEALARGKKAGRICVVRDGYFRYPAGSHVVFYRETD
ETIDVIRVLHQRMDIERHL

Download         Length: 300 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8708.68 Da        Isoelectric Point: 7.3196

>AT253703 WP_021033199.1 NZ_CP102475:c2246074-2245829 [Burkholderia cenocepacia]
MSRNTSVSLGDHFAEFVDAQVRSGRYGSASDVVRAGLRLLESHETQMRALQEALKAGEGSGTPKPFDSEAFLARMRATHG
G

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References