253702

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2081952..2083699 Replicon chromosome
Accession NZ_CP102473
Organism Burkholderia multivorans strain NML140411

Toxin (Protein)


Gene name doc Uniprot ID B9BHC0
Locus tag NUJ31_RS25195 Protein ID WP_006403210.1
Coordinates 2081952..2082848 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B9AZJ2
Locus tag NUJ31_RS25200 Protein ID WP_006396780.1
Coordinates 2082845..2083699 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ31_RS25165 (NUJ31_25165) 2077351..2078430 - 1080 WP_217050459.1 porin -
NUJ31_RS25170 (NUJ31_25170) 2078867..2079184 + 318 WP_053298416.1 non-heme iron oxygenase ferredoxin subunit -
NUJ31_RS25175 (NUJ31_25175) 2079186..2079497 + 312 WP_053298417.1 hypothetical protein -
NUJ31_RS25180 (NUJ31_25180) 2079545..2080615 + 1071 WP_006403208.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
NUJ31_RS25185 (NUJ31_25185) 2080608..2081378 + 771 WP_059940455.1 SDR family oxidoreductase -
NUJ31_RS25190 (NUJ31_25190) 2081406..2081933 + 528 WP_006396778.1 cupin domain-containing protein -
NUJ31_RS25195 (NUJ31_25195) 2081952..2082848 + 897 WP_006403210.1 alpha/beta fold hydrolase Toxin
NUJ31_RS25200 (NUJ31_25200) 2082845..2083699 + 855 WP_006396780.1 IclR family transcriptional regulator Antitoxin
NUJ31_RS25205 (NUJ31_25205) 2083696..2084493 + 798 WP_006396781.1 SDR family oxidoreductase -
NUJ31_RS25210 (NUJ31_25210) 2084486..2086153 + 1668 WP_053298420.1 thiamine pyrophosphate-binding protein -
NUJ31_RS25215 (NUJ31_25215) 2086146..2086976 + 831 WP_006403212.1 aspartate dehydrogenase -
NUJ31_RS25220 (NUJ31_25220) 2087038..2088528 + 1491 WP_006403213.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, N-terminal

(23-71)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30544.80 Da        Isoelectric Point: 8.0446

>T253702 WP_006403210.1 NZ_CP102473:2081952-2082848 [Burkholderia multivorans]
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQQAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDAFCRQCDIERRAA

Download         Length: 897 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31176.75 Da        Isoelectric Point: 6.6558

>AT253702 WP_006396780.1 NZ_CP102473:2082845-2083699 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9BHC0

Antitoxin

Source ID Structure
AlphaFold DB B9AZJ2

References