253699

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 774100..774720 Replicon chromosome
Accession NZ_CP102473
Organism Burkholderia multivorans strain NML140411

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag NUJ31_RS19490 Protein ID WP_012217495.1
Coordinates 774100..774417 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag NUJ31_RS19495 Protein ID WP_006398012.1
Coordinates 774421..774720 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ31_RS19480 (NUJ31_19480) 770633..772066 - 1434 WP_006404214.1 aldehyde dehydrogenase family protein -
NUJ31_RS19485 (NUJ31_19485) 772095..773735 - 1641 WP_006398015.1 acetolactate synthase large subunit -
NUJ31_RS19490 (NUJ31_19490) 774100..774417 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUJ31_RS19495 (NUJ31_19495) 774421..774720 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
NUJ31_RS19500 (NUJ31_19500) 774755..776041 - 1287 WP_053297867.1 DUF445 domain-containing protein -
NUJ31_RS19505 (NUJ31_19505) 776156..777376 - 1221 WP_105848031.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
NUJ31_RS19510 (NUJ31_19510) 777366..777692 - 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
NUJ31_RS19515 (NUJ31_19515) 777710..778198 - 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
NUJ31_RS19520 (NUJ31_19520) 778213..779484 - 1272 WP_217050643.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T253699 WP_012217495.1 NZ_CP102473:774100-774417 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT253699 WP_006398012.1 NZ_CP102473:774421-774720 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References