253698

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 2517649..2518349 Replicon chromosome
Accession NZ_CP102472
Organism Burkholderia multivorans strain NML140411

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag NUJ31_RS11825 Protein ID WP_217045821.1
Coordinates 2517649..2518026 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID B9BQB8
Locus tag NUJ31_RS11830 Protein ID WP_006405635.1
Coordinates 2518026..2518349 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ31_RS11795 (NUJ31_11795) 2513192..2513638 + 447 WP_217051764.1 VOC family protein -
NUJ31_RS11800 (NUJ31_11800) 2513742..2515292 - 1551 WP_006398698.1 sodium:solute symporter family protein -
NUJ31_RS11805 (NUJ31_11805) 2515289..2515522 - 234 WP_006398697.1 DUF3311 domain-containing protein -
NUJ31_RS11810 (NUJ31_11810) 2515719..2516636 - 918 WP_105774162.1 spermidine synthase -
NUJ31_RS11815 (NUJ31_11815) 2516865..2517119 + 255 WP_059940739.1 hypothetical protein -
NUJ31_RS11820 (NUJ31_11820) 2517296..2517664 - 369 WP_181146446.1 hypothetical protein -
NUJ31_RS11825 (NUJ31_11825) 2517649..2518026 + 378 WP_217045821.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUJ31_RS11830 (NUJ31_11830) 2518026..2518349 + 324 WP_006405635.1 helix-turn-helix transcriptional regulator Antitoxin
NUJ31_RS11835 (NUJ31_11835) 2518372..2518863 - 492 WP_070553236.1 DNA-deoxyinosine glycosylase -
NUJ31_RS11840 (NUJ31_11840) 2518860..2519474 - 615 WP_217045819.1 chorismate lyase -
NUJ31_RS11845 (NUJ31_11845) 2519483..2521381 - 1899 WP_217045817.1 molecular chaperone HtpG -
NUJ31_RS11850 (NUJ31_11850) 2521540..2523000 - 1461 WP_006405639.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-114)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13557.60 Da        Isoelectric Point: 9.7722

>T253698 WP_217045821.1 NZ_CP102472:2517649-2518026 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVRDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEHSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLSAAEAHANGEK

Download         Length: 378 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11828.69 Da        Isoelectric Point: 8.0686

>AT253698 WP_006405635.1 NZ_CP102472:2518026-2518349 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B9BQB8

References