253697

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 152627..153264 Replicon chromosome
Accession NZ_CP102472
Organism Burkholderia multivorans strain NML140411

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NUJ31_RS00670 Protein ID WP_217051603.1
Coordinates 152863..153264 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A132EWB1
Locus tag NUJ31_RS00665 Protein ID WP_006408845.1
Coordinates 152627..152863 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ31_RS00645 (NUJ31_00645) 147789..148331 + 543 WP_006408276.1 hypothetical protein -
NUJ31_RS00650 (NUJ31_00650) 148502..149533 + 1032 WP_105838574.1 helix-turn-helix domain-containing protein -
NUJ31_RS00655 (NUJ31_00655) 149652..150740 - 1089 WP_217051604.1 ADP-heptose--LPS heptosyltransferase -
NUJ31_RS00660 (NUJ31_00660) 150737..152440 - 1704 WP_105765206.1 thiamine pyrophosphate-binding protein -
NUJ31_RS00665 (NUJ31_00665) 152627..152863 + 237 WP_006408845.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NUJ31_RS00670 (NUJ31_00670) 152863..153264 + 402 WP_217051603.1 type II toxin-antitoxin system VapC family toxin Toxin
NUJ31_RS00675 (NUJ31_00675) 153386..154774 - 1389 WP_263074803.1 L-serine ammonia-lyase -
NUJ31_RS00680 (NUJ31_00680) 154801..155943 - 1143 WP_006401424.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14956.19 Da        Isoelectric Point: 6.2246

>T253697 WP_217051603.1 NZ_CP102472:152863-153264 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTVCANPARERRNLAALIEDIPVAPFDGAAAQA
YGPIREATRERKKDHLDKLIGVHAVSLDVVLVTNHERDFAGYPGLRLENWLVG

Download         Length: 402 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8915.00 Da        Isoelectric Point: 5.8651

>AT253697 WP_006408845.1 NZ_CP102472:152627-152863 [Burkholderia multivorans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREGW

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A132EWB1

References