Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 231681..232275 Replicon plasmid unnamed1
Accession NZ_CP102465
Organism Burkholderia contaminans strain NML151013

Toxin (Protein)


Gene name PumA Uniprot ID A0A228JB64
Locus tag NUJ29_RS39420 Protein ID WP_027811055.1
Coordinates 231681..231974 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A228JAU5
Locus tag NUJ29_RS39425 Protein ID WP_027811056.1
Coordinates 231976..232275 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ29_RS39395 (NUJ29_39395) 227064..229274 + 2211 WP_226251535.1 ParB/RepB/Spo0J family partition protein -
NUJ29_RS39400 (NUJ29_39400) 230318..230584 + 267 WP_027811052.1 hypothetical protein -
NUJ29_RS39405 (NUJ29_39405) 230559..231110 + 552 WP_077186813.1 hypothetical protein -
NUJ29_RS39410 (NUJ29_39410) 231155..231376 + 222 WP_027811054.1 DUF3717 domain-containing protein -
NUJ29_RS39415 (NUJ29_39415) 231433..231576 + 144 WP_154233621.1 hypothetical protein -
NUJ29_RS39420 (NUJ29_39420) 231681..231974 + 294 WP_027811055.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUJ29_RS39425 (NUJ29_39425) 231976..232275 + 300 WP_027811056.1 putative addiction module antidote protein Antitoxin
NUJ29_RS39430 (NUJ29_39430) 232438..232749 - 312 WP_027811057.1 hypothetical protein -
NUJ29_RS39435 (NUJ29_39435) 232997..233500 - 504 WP_143277545.1 hypothetical protein -
NUJ29_RS39440 (NUJ29_39440) 234517..234918 + 402 WP_027811058.1 hypothetical protein -
NUJ29_RS39445 (NUJ29_39445) 234911..236977 + 2067 WP_027811059.1 type IV secretion system DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..240894 240894


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-87)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10854.50 Da        Isoelectric Point: 10.6086

>T253696 WP_027811055.1 NZ_CP102465:231681-231974 [Burkholderia contaminans]
MRIEQTDDFAKWLRGLRDHIARAQIAKRIQRLARGQYGDMKPVGAGVSEMRVHVGPGYRVYFVQRGSTLVVLLCGGDKST
QQRDIERAIALSAQLGD

Download         Length: 294 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10716.01 Da        Isoelectric Point: 4.6364

>AT253696 WP_027811056.1 NZ_CP102465:231976-232275 [Burkholderia contaminans]
MGIKTTPFDAAEYLDTPEAQAEYLRISFETGDSADIQEAIGTVARARGMTQIARDAGVGRESLYKALDEHGNPEFATILR
VVRALGLTLTVTTPVHEHA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A228JB64

Antitoxin

Source ID Structure
AlphaFold DB A0A228JAU5

References