Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 2833196..2833829 Replicon chromosome
Accession NZ_CP102463
Organism Burkholderia contaminans strain NML151013

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NUJ29_RS30825 Protein ID WP_105815256.1
Coordinates 2833416..2833829 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2S9P9A2
Locus tag NUJ29_RS30820 Protein ID WP_071333622.1
Coordinates 2833196..2833429 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ29_RS30805 (NUJ29_30805) 2828219..2829913 + 1695 WP_105815258.1 VRR-NUC domain-containing protein -
NUJ29_RS30810 (NUJ29_30810) 2829910..2832210 + 2301 WP_105815257.1 ATP-dependent DNA helicase -
NUJ29_RS30815 (NUJ29_30815) 2832259..2833029 - 771 WP_039367494.1 IclR family transcriptional regulator C-terminal domain-containing protein -
NUJ29_RS30820 (NUJ29_30820) 2833196..2833429 + 234 WP_071333622.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NUJ29_RS30825 (NUJ29_30825) 2833416..2833829 + 414 WP_105815256.1 PIN domain-containing protein Toxin
NUJ29_RS30830 (NUJ29_30830) 2833979..2834392 - 414 WP_105815255.1 hypothetical protein -
NUJ29_RS30835 (NUJ29_30835) 2834664..2835275 + 612 WP_105815254.1 hypothetical protein -
NUJ29_RS30840 (NUJ29_30840) 2835347..2836648 - 1302 WP_039367440.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
NUJ29_RS30845 (NUJ29_30845) 2836866..2838170 - 1305 WP_105815253.1 shikimate transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-119)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15208.44 Da        Isoelectric Point: 4.7627

>T253692 WP_105815256.1 NZ_CP102463:2833416-2833829 [Burkholderia contaminans]
MSGIDATKSFVDSNVVLYLLSEDETKADRAESLLLRRPTISVQVLNEVASVCSRKLRMPWFDVGQFLEPIRSLCRVVPIS
VDTHDLGRKLAERHGLSFYDACIVASATIEGCEYLYTEDMHDGLCVEGGPVLKNPFA

Download         Length: 414 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8804.10 Da        Isoelectric Point: 8.8306

>AT253692 WP_071333622.1 NZ_CP102463:2833196-2833429 [Burkholderia contaminans]
MLVAKWGNSLAVRLPASVVDALELREGDDIEIVVDSPRVFAVSRKPRPEELLQRLRRFRGKLPADFKFGRDDANERD

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9P9A2

References