Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2104574..2105194 Replicon chromosome
Accession NZ_CP102463
Organism Burkholderia contaminans strain NML151013

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NUJ29_RS27610 Protein ID WP_249362359.1
Coordinates 2104877..2105194 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1J9PWC2
Locus tag NUJ29_RS27605 Protein ID WP_039344756.1
Coordinates 2104574..2104873 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ29_RS27580 (NUJ29_27580) 2099737..2101008 + 1272 WP_105818955.1 anthranilate 1,2-dioxygenase large subunit AndAc -
NUJ29_RS27585 (NUJ29_27585) 2101023..2101511 + 489 WP_011355917.1 anthranilate 1,2-dioxygenase small subunit AndAd -
NUJ29_RS27590 (NUJ29_27590) 2101532..2101858 + 327 WP_039344765.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
NUJ29_RS27595 (NUJ29_27595) 2101848..2103068 + 1221 WP_105818954.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
NUJ29_RS27600 (NUJ29_27600) 2103239..2104525 + 1287 WP_105818953.1 DUF445 domain-containing protein -
NUJ29_RS27605 (NUJ29_27605) 2104574..2104873 - 300 WP_039344756.1 putative addiction module antidote protein Antitoxin
NUJ29_RS27610 (NUJ29_27610) 2104877..2105194 - 318 WP_249362359.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUJ29_RS27615 (NUJ29_27615) 2105547..2107187 + 1641 WP_105818951.1 acetolactate synthase large subunit -
NUJ29_RS27620 (NUJ29_27620) 2107217..2108650 + 1434 WP_105818950.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-100)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11854.57 Da        Isoelectric Point: 9.5691

>T253691 WP_249362359.1 NZ_CP102463:c2105194-2104877 [Burkholderia contaminans]
MPYSAPTFSIRTTDVFDTWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRGTIWVILL
CGGDKSSQQADIRAAHAMLAHLDME

Download         Length: 318 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10649.01 Da        Isoelectric Point: 6.3217

>AT253691 WP_039344756.1 NZ_CP102463:c2104873-2104574 [Burkholderia contaminans]
MDKISTRPWDSADHLKTEDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9PWC2

References