25369

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/GNAT-DUF1778
Location 3458283..3459055 Replicon chromosome
Accession NC_015656
Organism Frankia symbiont of Datisca glomerata

Toxin (Protein)


Gene name tacT Uniprot ID F8B6M3
Locus tag FSYMDG_RS14365 Protein ID WP_013874133.1
Coordinates 3458543..3459055 (+) Length 171 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID F8B6M2
Locus tag FSYMDG_RS14360 Protein ID WP_013874132.1
Coordinates 3458283..3458546 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FSYMDG_RS14350 3454302..3456104 - 1803 WP_013874130.1 AMP-dependent synthetase/ligase -
FSYMDG_RS14355 3456648..3458174 + 1527 WP_013874131.1 MFS transporter -
FSYMDG_RS14360 3458283..3458546 + 264 WP_013874132.1 DUF1778 domain-containing protein Antitoxin
FSYMDG_RS14365 3458543..3459055 + 513 WP_013874133.1 GNAT family N-acetyltransferase Toxin
FSYMDG_RS14370 3459507..3460070 + 564 WP_083828497.1 PaaI family thioesterase -
FSYMDG_RS14375 3460113..3460796 - 684 WP_131774012.1 HAD family phosphatase -
FSYMDG_RS14380 3460866..3461717 - 852 WP_013874136.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-145)

Antitoxin

Vibrio phage ICP1, Orf50

(6-81)


Sequences

Toxin        


Download         Length: 171 a.a.        Molecular weight: 18372.93 Da        Isoelectric Point: 9.0667

>T25369 WP_013874133.1 NC_015656:3458543-3459055 [Candidatus Frankia datiscae]
VSGYSAPRPIAAADDLSTFDSGESSLDDWLRRRALGNQTAGASRCFVTCRDGRVVGYYALATGAVQRLDTSRRIGQGMPD
PVPVILLGRLAVDVKEQGRGLGAHLLRDAITRTVAAAEIVGVRALLVHALHDQARQFYLYFGFEPSPTHPLHLFLLMKDA
RALTRGDTSG

Download         Length: 513 bp

>T25369 NC_015656:3458543-3459055 [Candidatus Frankia datiscae]
GTGAGTGGTTACTCCGCACCCAGGCCGATCGCCGCGGCTGATGACCTGTCGACCTTTGACAGCGGCGAGTCCTCACTGGA
CGACTGGTTGCGCCGACGGGCGTTGGGTAACCAGACAGCGGGAGCCTCCCGCTGCTTTGTCACGTGCCGTGACGGACGTG
TCGTCGGCTACTACGCCCTGGCTACCGGAGCTGTACAGCGGCTGGACACCAGCCGACGCATCGGCCAGGGCATGCCCGAT
CCCGTCCCGGTCATTCTGCTGGGGCGTCTCGCCGTCGACGTCAAGGAACAGGGCCGGGGTCTGGGCGCCCATCTGTTACG
CGACGCGATCACCCGCACCGTCGCGGCAGCGGAGATCGTCGGTGTGCGAGCCCTGCTCGTACACGCGCTGCACGACCAGG
CTCGGCAGTTCTACCTGTATTTCGGGTTTGAACCGTCTCCCACCCATCCGCTCCATCTGTTCCTTCTGATGAAGGATGCC
CGGGCTCTGACCAGAGGCGACACATCCGGGTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9821.27 Da        Isoelectric Point: 5.1745

>AT25369 WP_013874132.1 NC_015656:3458283-3458546 [Candidatus Frankia datiscae]
MIKSSRIAVRLPEEQDALIRAAAEVEGSTVTEFTVNAAVARAKDVLADQRLFTLGSEAWTEFLTILDRPVTRKPRLERLF
TEKSIFE

Download         Length: 264 bp

>AT25369 NC_015656:3458283-3458546 [Candidatus Frankia datiscae]
ATGATCAAAAGTTCCCGCATCGCTGTGCGCCTGCCTGAAGAGCAGGATGCGCTGATCCGCGCGGCAGCCGAGGTCGAAGG
CTCGACCGTCACCGAGTTCACCGTGAATGCGGCCGTAGCCAGGGCCAAGGACGTCCTGGCAGACCAGCGCCTGTTCACAC
TGGGGAGCGAGGCATGGACGGAGTTCCTCACCATTCTGGATCGTCCGGTTACCCGCAAACCGCGCCTGGAACGCCTGTTC
ACCGAGAAGTCGATCTTTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8B6M3

Antitoxin

Source ID Structure
AlphaFold DB F8B6M2

References