Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 128056..129806 Replicon chromosome
Accession NZ_CP102463
Organism Burkholderia contaminans strain NML151013

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NUJ29_RS18655 Protein ID WP_105818004.1
Coordinates 128910..129806 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag NUJ29_RS18650 Protein ID WP_105818003.1
Coordinates 128056..128913 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ29_RS18630 (NUJ29_18630) 123219..124709 - 1491 WP_071332351.1 aldehyde dehydrogenase -
NUJ29_RS18635 (NUJ29_18635) 124782..125609 - 828 WP_047849734.1 aspartate dehydrogenase -
NUJ29_RS18640 (NUJ29_18640) 125602..127269 - 1668 WP_105818001.1 thiamine pyrophosphate-binding protein -
NUJ29_RS18645 (NUJ29_18645) 127262..128059 - 798 WP_105818002.1 SDR family oxidoreductase -
NUJ29_RS18650 (NUJ29_18650) 128056..128913 - 858 WP_105818003.1 IclR family transcriptional regulator Antitoxin
NUJ29_RS18655 (NUJ29_18655) 128910..129806 - 897 WP_105818004.1 alpha/beta fold hydrolase Toxin
NUJ29_RS18660 (NUJ29_18660) 129825..130352 - 528 WP_039344094.1 cupin domain-containing protein -
NUJ29_RS18665 (NUJ29_18665) 130390..131160 - 771 WP_039344092.1 SDR family oxidoreductase -
NUJ29_RS18670 (NUJ29_18670) 131153..132229 - 1077 WP_039344090.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
NUJ29_RS18675 (NUJ29_18675) 132282..132593 - 312 WP_039344088.1 hypothetical protein -
NUJ29_RS18680 (NUJ29_18680) 132595..132912 - 318 WP_011354710.1 non-heme iron oxygenase ferredoxin subunit -
NUJ29_RS18685 (NUJ29_18685) 133357..134436 + 1080 WP_039344086.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30716.99 Da        Isoelectric Point: 8.0624

>T253689 WP_105818004.1 NZ_CP102463:c129806-128910 [Burkholderia contaminans]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYRESGAHHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLIRVMPARIAGLLLVSPAGGYGSAPAETR
DARRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATQLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDQQRGLA

Download         Length: 897 bp

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31433.00 Da        Isoelectric Point: 6.7661

>AT253689 WP_105818003.1 NZ_CP102463:c128913-128056 [Burkholderia contaminans]
MNEPLQRPELENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References