Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 2930579..2931261 Replicon chromosome
Accession NZ_CP102462
Organism Burkholderia contaminans strain NML151013

Toxin (Protein)


Gene name tad Uniprot ID A0A6P2YP52
Locus tag NUJ29_RS13845 Protein ID WP_046544690.1
Coordinates 2930579..2930941 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag NUJ29_RS13850 Protein ID WP_046544689.1
Coordinates 2930938..2931261 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ29_RS13820 (NUJ29_13820) 2926402..2926857 + 456 WP_105818698.1 VOC family protein -
NUJ29_RS13825 (NUJ29_13825) 2926925..2928475 - 1551 WP_039370375.1 sodium:solute symporter family protein -
NUJ29_RS13830 (NUJ29_13830) 2928472..2928714 - 243 WP_011352801.1 DUF3311 domain-containing protein -
NUJ29_RS13835 (NUJ29_13835) 2928913..2929830 - 918 WP_105818697.1 spermidine synthase -
NUJ29_RS13840 (NUJ29_13840) 2929975..2930229 + 255 WP_071334800.1 hypothetical protein -
NUJ29_RS13845 (NUJ29_13845) 2930579..2930941 + 363 WP_046544690.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUJ29_RS13850 (NUJ29_13850) 2930938..2931261 + 324 WP_046544689.1 helix-turn-helix transcriptional regulator Antitoxin
NUJ29_RS13855 (NUJ29_13855) 2931323..2931799 - 477 WP_105818696.1 DNA-deoxyinosine glycosylase -
NUJ29_RS13860 (NUJ29_13860) 2931799..2932395 - 597 WP_039370667.1 chorismate lyase -
NUJ29_RS13865 (NUJ29_13865) 2932404..2934302 - 1899 WP_047852434.1 molecular chaperone HtpG -
NUJ29_RS13870 (NUJ29_13870) 2934461..2935921 - 1461 WP_039370360.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13299.24 Da        Isoelectric Point: 9.9311

>T253688 WP_046544690.1 NZ_CP102462:2930579-2930941 [Burkholderia contaminans]
MDPYIKPLYWLGSARKDLKAMPQAVQDTFGYALYLAQTGRKHDQAKPLKGFGSAGVLEIVESEDNGTYRAVYTVKLGSSV
YVLHCFQKKSSIGIATPRPDSDLVRERLKAAEAHAQGVRR

Download         Length: 363 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11806.68 Da        Isoelectric Point: 7.3600

>AT253688 WP_046544689.1 NZ_CP102462:2930938-2931261 [Burkholderia contaminans]
MIEIEQGSGNVYADLGMHDAAEMRVKAQLAAKIAEIIKARQWTQQHAARLLGITQPKLSNMLRGQFRGVSETKMLECLAK
LGRDVHIVVGPDRQSEVEGHIEVVFAA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P2YP52

Antitoxin

Source ID Structure

References