Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 189796..190433 Replicon chromosome
Accession NZ_CP102462
Organism Burkholderia contaminans strain NML151013

Toxin (Protein)


Gene name vapC Uniprot ID A0A228K4S8
Locus tag NUJ29_RS00860 Protein ID WP_039351354.1
Coordinates 190032..190433 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1E3FXY0
Locus tag NUJ29_RS00855 Protein ID WP_039351357.1
Coordinates 189796..190032 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ29_RS00840 (NUJ29_00840) 185482..186513 + 1032 WP_105815479.1 helix-turn-helix domain-containing protein -
NUJ29_RS00845 (NUJ29_00845) 186637..187734 - 1098 WP_105815480.1 ADP-heptose--LPS heptosyltransferase -
NUJ29_RS00850 (NUJ29_00850) 187731..189434 - 1704 WP_105815481.1 thiamine pyrophosphate-binding protein -
NUJ29_RS00855 (NUJ29_00855) 189796..190032 + 237 WP_039351357.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NUJ29_RS00860 (NUJ29_00860) 190032..190433 + 402 WP_039351354.1 type II toxin-antitoxin system VapC family toxin Toxin
NUJ29_RS00865 (NUJ29_00865) 190504..191892 - 1389 WP_105815482.1 L-serine ammonia-lyase -
NUJ29_RS00870 (NUJ29_00870) 191923..193026 - 1104 WP_224755992.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14880.98 Da        Isoelectric Point: 4.7249

>T253686 WP_039351354.1 NZ_CP102462:190032-190433 [Burkholderia contaminans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVAACASPARERGNLAALIDDIPVAPFDVAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLDD

Download         Length: 402 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9008.13 Da        Isoelectric Point: 6.4720

>AT253686 WP_039351357.1 NZ_CP102462:189796-190032 [Burkholderia contaminans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTRVLEKFAKFGPDFMADGRGDHEQADREGL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A228K4S8

Antitoxin

Source ID Structure
AlphaFold DB A0A1E3FXY0

References