Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 369873..370564 Replicon chromosome
Accession NZ_CP102459
Organism Burkholderia multivorans strain NML180963

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NUJ28_RS18450 Protein ID WP_059874917.1
Coordinates 369873..370328 (-) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2S9M8Q6
Locus tag NUJ28_RS18455 Protein ID WP_059874916.1
Coordinates 370325..370564 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ28_RS18425 (NUJ28_18425) 364972..365766 + 795 WP_105821753.1 AraC family transcriptional regulator -
NUJ28_RS18430 (NUJ28_18430) 366281..367231 + 951 WP_105822030.1 DMT family transporter -
NUJ28_RS18435 (NUJ28_18435) 367442..368017 + 576 WP_105821977.1 permease -
NUJ28_RS18440 (NUJ28_18440) 368113..368247 - 135 WP_006396654.1 entericidin A/B family lipoprotein -
NUJ28_RS18445 (NUJ28_18445) 368480..369775 + 1296 WP_035487510.1 aspartate carbamoyltransferase -
NUJ28_RS18450 (NUJ28_18450) 369873..370328 - 456 WP_059874917.1 type II toxin-antitoxin system VapC family toxin Toxin
NUJ28_RS18455 (NUJ28_18455) 370325..370564 - 240 WP_059874916.1 Arc family DNA-binding protein Antitoxin
NUJ28_RS18460 (NUJ28_18460) 370869..373115 + 2247 WP_176035228.1 TonB-dependent siderophore receptor -
NUJ28_RS18465 (NUJ28_18465) 373119..373874 + 756 WP_105821978.1 tetratricopeptide repeat protein -
NUJ28_RS18470 (NUJ28_18470) 373871..374554 + 684 WP_035955277.1 Fe2+-dependent dioxygenase -
NUJ28_RS18475 (NUJ28_18475) 374960..375199 + 240 WP_006416205.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16251.60 Da        Isoelectric Point: 6.4793

>T253683 WP_059874917.1 NZ_CP102459:c370328-369873 [Burkholderia multivorans]
MILVDTNVIAEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK

Download         Length: 456 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8686.91 Da        Isoelectric Point: 5.1133

>AT253683 WP_059874916.1 NZ_CP102459:c370564-370325 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPADPMSFE

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9M8Q6

References