Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 257970..259717 Replicon chromosome
Accession NZ_CP102459
Organism Burkholderia multivorans strain NML180963

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NUJ28_RS17905 Protein ID WP_105821784.1
Coordinates 258821..259717 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag NUJ28_RS17900 Protein ID WP_048804599.1
Coordinates 257970..258824 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ28_RS17880 (NUJ28_17880) 253125..254615 - 1491 WP_105821786.1 aldehyde dehydrogenase -
NUJ28_RS17885 (NUJ28_17885) 254693..255523 - 831 WP_006396783.1 aspartate dehydrogenase -
NUJ28_RS17890 (NUJ28_17890) 255516..257183 - 1668 WP_012216808.1 thiamine pyrophosphate-binding protein -
NUJ28_RS17895 (NUJ28_17895) 257176..257973 - 798 WP_105821785.1 SDR family oxidoreductase -
NUJ28_RS17900 (NUJ28_17900) 257970..258824 - 855 WP_048804599.1 IclR family transcriptional regulator Antitoxin
NUJ28_RS17905 (NUJ28_17905) 258821..259717 - 897 WP_105821784.1 alpha/beta fold hydrolase Toxin
NUJ28_RS17910 (NUJ28_17910) 259736..260263 - 528 WP_006396778.1 cupin domain-containing protein -
NUJ28_RS17915 (NUJ28_17915) 260291..261061 - 771 WP_105821783.1 SDR family oxidoreductase -
NUJ28_RS17920 (NUJ28_17920) 261054..262124 - 1071 WP_006413805.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
NUJ28_RS17925 (NUJ28_17925) 262172..262483 - 312 WP_006396775.1 hypothetical protein -
NUJ28_RS17930 (NUJ28_17930) 262485..262802 - 318 WP_006396774.1 non-heme iron oxygenase ferredoxin subunit -
NUJ28_RS17935 (NUJ28_17935) 263239..264318 + 1080 WP_039217461.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, N-terminal

(23-71)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30627.89 Da        Isoelectric Point: 8.0534

>T253682 WP_105821784.1 NZ_CP102459:c259717-258821 [Burkholderia multivorans]
MSVVDKRERDRTAAFATLLERFPEQRCASGAAGTIGYREAGAQHAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAVAGVGLQVIPQAGHAGYVEAPDVYSALIDTFCRQCDIERRAA

Download         Length: 897 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31118.71 Da        Isoelectric Point: 6.9856

>AT253682 WP_048804599.1 NZ_CP102459:c258824-257970 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDALRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References