Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2594349..2594959 Replicon chromosome
Accession NZ_CP102458
Organism Burkholderia multivorans strain NML180963

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NUJ28_RS12610 Protein ID WP_176034435.1
Coordinates 2594651..2594959 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NUJ28_RS12605 Protein ID WP_176034436.1
Coordinates 2594349..2594654 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ28_RS12570 (NUJ28_12570) 2590203..2590682 - 480 WP_176034440.1 hypothetical protein -
NUJ28_RS12575 (NUJ28_12575) 2591205..2591513 - 309 WP_261531626.1 integrase domain-containing protein -
NUJ28_RS12580 (NUJ28_12580) 2591413..2591766 - 354 WP_261531627.1 integrase domain-containing protein -
NUJ28_RS12585 (NUJ28_12585) 2591994..2592251 - 258 WP_176034439.1 hypothetical protein -
NUJ28_RS12590 (NUJ28_12590) 2592202..2592526 - 325 Protein_2451 SOS response-associated peptidase -
NUJ28_RS12595 (NUJ28_12595) 2592643..2593116 - 474 WP_176034438.1 hypothetical protein -
NUJ28_RS12600 (NUJ28_12600) 2593113..2594003 - 891 WP_176034437.1 endonuclease/exonuclease/phosphatase family protein -
NUJ28_RS12605 (NUJ28_12605) 2594349..2594654 - 306 WP_176034436.1 putative addiction module antidote protein Antitoxin
NUJ28_RS12610 (NUJ28_12610) 2594651..2594959 - 309 WP_176034435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUJ28_RS12615 (NUJ28_12615) 2595631..2595876 + 246 WP_006398667.1 hypothetical protein -
NUJ28_RS12620 (NUJ28_12620) 2595899..2596669 - 771 WP_176034434.1 SDR family oxidoreductase -
NUJ28_RS12625 (NUJ28_12625) 2596831..2598858 + 2028 WP_263130135.1 protein-L-isoaspartate(D-aspartate) O-methyltransferase -
NUJ28_RS12630 (NUJ28_12630) 2598985..2599725 - 741 WP_176034432.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2574004..2594959 20955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(7-98)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11639.13 Da        Isoelectric Point: 8.9317

>T253681 WP_176034435.1 NZ_CP102458:c2594959-2594651 [Burkholderia multivorans]
MNTINQTGEFQEWLRDLKDKVGRGAILGRINRARLGNFGDHKDLGDGVSEMRIDVGPGYRVYFGRDGKDIYLLICGGDKS
SQDKDIKHAKAIWEQFRKEQQP

Download         Length: 309 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10789.35 Da        Isoelectric Point: 4.8232

>AT253681 WP_176034436.1 NZ_CP102458:c2594654-2594349 [Burkholderia multivorans]
MTTTEAIKVTPFDASEYLDDEETIASYISAAMEADDQDVLLLALADVAKARGMAKVAADAGLGRESLYKALKPGANPKYE
TVNKLMHALGIKFAAVPNRKS

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References