253678

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5036560..5038255 Replicon chromosome
Accession NZ_CP102441
Organism Pseudomonas aeruginosa strain PA30

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag NR803_RS23575 Protein ID WP_003112901.1
Coordinates 5037386..5038255 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag NR803_RS23570 Protein ID WP_003112902.1
Coordinates 5036560..5037393 (-) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR803_RS23550 (NR803_23550) 5031791..5033275 - 1485 WP_031756606.1 aldehyde dehydrogenase -
NR803_RS23555 (NR803_23555) 5033287..5034090 - 804 WP_003453564.1 aspartate dehydrogenase -
NR803_RS23560 (NR803_23560) 5034101..5035783 - 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
NR803_RS23565 (NR803_23565) 5035776..5036573 - 798 WP_017001845.1 SDR family oxidoreductase -
NR803_RS23570 (NR803_23570) 5036560..5037393 - 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
NR803_RS23575 (NR803_23575) 5037386..5038255 - 870 WP_003112901.1 alpha/beta hydrolase Toxin
NR803_RS23580 (NR803_23580) 5038264..5038794 - 531 WP_003112900.1 cupin domain-containing protein -
NR803_RS23585 (NR803_23585) 5038808..5039569 - 762 WP_003112899.1 SDR family oxidoreductase -
NR803_RS23590 (NR803_23590) 5039575..5040351 - 777 WP_003112898.1 ABC transporter permease -
NR803_RS23595 (NR803_23595) 5040348..5041355 - 1008 WP_003162724.1 ABC transporter substrate-binding protein -
NR803_RS23600 (NR803_23600) 5041396..5042247 - 852 WP_003130104.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T253678 WP_003112901.1 NZ_CP102441:c5038255-5037386 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT253678 WP_003112902.1 NZ_CP102441:c5037393-5036560 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References