253677

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 4766282..4767790 Replicon chromosome
Accession NZ_CP102441
Organism Pseudomonas aeruginosa strain PA30

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag NR803_RS22315 Protein ID WP_003119682.1
Coordinates 4767203..4767790 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag NR803_RS22310 Protein ID WP_003119683.1
Coordinates 4766282..4767136 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR803_RS22295 (NR803_22295) 4761701..4761910 + 210 WP_003091604.1 cold-shock protein -
NR803_RS22300 (NR803_22300) 4761971..4763845 - 1875 WP_003091605.1 MFS transporter -
NR803_RS22305 (NR803_22305) 4764020..4766185 - 2166 WP_003091606.1 TonB-dependent receptor family protein -
NR803_RS22310 (NR803_22310) 4766282..4767136 - 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
NR803_RS22315 (NR803_22315) 4767203..4767790 - 588 WP_003119682.1 GNAT family protein Toxin
NR803_RS22320 (NR803_22320) 4768056..4771535 + 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T253677 WP_003119682.1 NZ_CP102441:c4767790-4767203 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT253677 WP_003119683.1 NZ_CP102441:c4767136-4766282 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References