Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2957473..2958693 Replicon chromosome
Accession NZ_CP102441
Organism Pseudomonas aeruginosa strain PA30

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NR803_RS14250 Protein ID WP_003160088.1
Coordinates 2957473..2958051 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NR803_RS14255 Protein ID WP_003088112.1
Coordinates 2958139..2958693 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR803_RS14235 (NR803_14240) 2952749..2954026 + 1278 WP_003102743.1 TolC family protein -
NR803_RS14240 (NR803_14245) 2954016..2956187 + 2172 WP_009876279.1 type I secretion system permease/ATPase -
NR803_RS14245 (NR803_14250) 2956177..2957364 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
NR803_RS14250 (NR803_14255) 2957473..2958051 - 579 WP_003160088.1 HD domain-containing protein Toxin
NR803_RS14255 (NR803_14260) 2958139..2958693 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
NR803_RS14260 (NR803_14265) 2958851..2961046 - 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
NR803_RS14265 (NR803_14270) 2961051..2961512 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
NR803_RS14270 (NR803_14275) 2961843..2962166 + 324 WP_003102734.1 multidrug efflux SMR transporter -
NR803_RS14275 (NR803_14280) 2962179..2962577 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
NR803_RS14280 (NR803_14285) 2962574..2963125 - 552 WP_003132721.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T253676 WP_003160088.1 NZ_CP102441:c2958051-2957473 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT253676 WP_003088112.1 NZ_CP102441:c2958693-2958139 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References