253675

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1952583..1953841 Replicon chromosome
Accession NZ_CP102441
Organism Pseudomonas aeruginosa strain PA30

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag NR803_RS09350 Protein ID WP_003112528.1
Coordinates 1953086..1953841 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag NR803_RS09345 Protein ID WP_003086329.1
Coordinates 1952583..1952951 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR803_RS09325 (NR803_09330) 1948746..1949021 + 276 WP_169057979.1 zinc ribbon domain-containing protein -
NR803_RS09330 (NR803_09335) 1949024..1949500 - 477 WP_003112531.1 hypothetical protein -
NR803_RS09335 (NR803_09340) 1949579..1951168 + 1590 WP_074231416.1 aldehyde dehydrogenase family protein -
NR803_RS09340 (NR803_09345) 1951224..1952510 + 1287 WP_003163134.1 FAD-binding oxidoreductase -
NR803_RS09345 (NR803_09350) 1952583..1952951 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
NR803_RS09350 (NR803_09355) 1953086..1953841 + 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
NR803_RS09355 (NR803_09360) 1954609..1955970 + 1362 WP_073647918.1 DNA recombination protein RmuC -
NR803_RS09360 (NR803_09365) 1956125..1958668 - 2544 WP_031755663.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T253675 WP_003112528.1 NZ_CP102441:1953086-1953841 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT253675 WP_003086329.1 NZ_CP102441:1952583-1952951 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References