253673

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 1017397..1017983 Replicon chromosome
Accession NZ_CP102441
Organism Pseudomonas aeruginosa strain PA30

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag NR803_RS04915 Protein ID WP_003120987.1
Coordinates 1017397..1017696 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag NR803_RS04920 Protein ID WP_003448662.1
Coordinates 1017693..1017983 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR803_RS04895 (NR803_04895) 1012510..1013043 - 534 WP_003099760.1 type IV pilus biogenesis protein PilP -
NR803_RS04900 (NR803_04900) 1013033..1014358 - 1326 WP_003099758.1 type 4b pilus protein PilO2 -
NR803_RS04905 (NR803_04905) 1014362..1016071 - 1710 WP_003099757.1 PilN family type IVB pilus formation outer membrane protein -
NR803_RS04910 (NR803_04910) 1016071..1017195 - 1125 WP_012076859.1 TcpQ domain-containing protein -
NR803_RS04915 (NR803_04915) 1017397..1017696 + 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NR803_RS04920 (NR803_04920) 1017693..1017983 + 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
NR803_RS04925 (NR803_04925) 1018054..1018398 - 345 WP_016851612.1 hypothetical protein -
NR803_RS04930 (NR803_04930) 1018395..1018529 - 135 WP_255253641.1 hypothetical protein -
NR803_RS04935 (NR803_04935) 1018539..1020515 - 1977 WP_016851611.1 DEAD/DEAH box helicase -
NR803_RS04940 (NR803_04940) 1020512..1022401 - 1890 WP_196994395.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 958800..1046012 87212


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T253673 WP_003120987.1 NZ_CP102441:1017397-1017696 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT253673 WP_003448662.1 NZ_CP102441:1017693-1017983 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References