25367

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 2971253..2971767 Replicon chromosome
Accession NC_015656
Organism Frankia symbiont of Datisca glomerata

Toxin (Protein)


Gene name relE Uniprot ID F8B583
Locus tag FSYMDG_RS12350 Protein ID WP_013873793.1
Coordinates 2971507..2971767 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID F8B280
Locus tag FSYMDG_RS12345 Protein ID WP_013873792.1
Coordinates 2971253..2971510 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FSYMDG_RS12315 2966832..2968160 - 1329 WP_013873787.1 histidinol-phosphate transaminase -
FSYMDG_RS12320 2968157..2969452 - 1296 WP_202797725.1 histidinol dehydrogenase -
FSYMDG_RS12325 2969610..2969897 + 288 WP_013873789.1 hypothetical protein -
FSYMDG_RS12330 2969897..2970277 + 381 WP_013873790.1 twitching motility protein PilT -
FSYMDG_RS12340 2970562..2970798 - 237 WP_083828259.1 hypothetical protein -
FSYMDG_RS24550 2970808..2971036 + 229 Protein_2429 hypothetical protein -
FSYMDG_RS12345 2971253..2971510 + 258 WP_013873792.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FSYMDG_RS12350 2971507..2971767 + 261 WP_013873793.1 Txe/YoeB family addiction module toxin Toxin
FSYMDG_RS12355 2971951..2972751 - 801 WP_043606230.1 SAM-dependent methyltransferase -
FSYMDG_RS12360 2973114..2974505 - 1392 WP_202797726.1 TIGR02679 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-70)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10228.60 Da        Isoelectric Point: 7.2754

>T25367 WP_013873793.1 NC_015656:2971507-2971767 [Candidatus Frankia datiscae]
MKLSWTDHAWEDYLYWQTQDRRTLKRISTLIADIKRDPDGSGIGKPEILRNNLAGLRSRRIDDEHRLVYAVEPGEIIIIS
CRYHYE

Download         Length: 261 bp

>T25367 NC_015656:2971507-2971767 [Candidatus Frankia datiscae]
TTGAAGCTCAGCTGGACCGACCACGCCTGGGAGGACTATCTCTACTGGCAGACCCAGGACCGCAGGACGCTCAAACGCAT
CAGCACCCTGATCGCTGATATCAAAAGGGACCCCGACGGTTCAGGTATCGGCAAGCCTGAGATTCTGCGTAACAACCTCG
CCGGTCTGCGCTCCCGCCGCATCGACGACGAGCACCGCCTCGTCTACGCAGTCGAACCCGGCGAGATCATCATCATCTCC
TGCCGTTACCACTACGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9476.62 Da        Isoelectric Point: 5.6864

>AT25367 WP_013873792.1 NC_015656:2971253-2971510 [Candidatus Frankia datiscae]
MTAAISASEARKTLFPLIERVNADHAPVEIVSKHGNAVLVSKEDWDSIMETNYLLRSPANAKRLTESIDQWRTGNARERD
LSPDA

Download         Length: 258 bp

>AT25367 NC_015656:2971253-2971510 [Candidatus Frankia datiscae]
ATGACGGCCGCGATCAGTGCGAGCGAGGCGCGCAAGACCCTGTTCCCGCTCATCGAGCGGGTCAACGCCGACCACGCCCC
CGTCGAGATCGTTTCCAAGCACGGCAACGCGGTTCTGGTCAGCAAGGAGGACTGGGACTCGATCATGGAGACCAACTACC
TGCTACGCTCCCCCGCCAACGCCAAGCGACTGACGGAGAGTATCGACCAGTGGCGTACTGGTAACGCCAGGGAGCGCGAC
CTGAGCCCGGACGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8B583

Antitoxin

Source ID Structure
AlphaFold DB F8B280

References