Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 111348..112084 Replicon plasmid unnamed1
Accession NZ_CP102439
Organism Klebsiella pneumoniae strain hvKP248

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag NUJ53_RS26415 Protein ID WP_004098919.1
Coordinates 111348..111830 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A7D3T1D0
Locus tag NUJ53_RS26420 Protein ID WP_004213599.1
Coordinates 111818..112084 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ53_RS26395 (NUJ53_26395) 106702..108048 + 1347 WP_011154555.1 dihydroorotase -
NUJ53_RS26400 (NUJ53_26400) 108112..109134 + 1023 WP_004214536.1 porphobilinogen synthase -
NUJ53_RS26405 (NUJ53_26405) 109309..109704 + 396 Protein_128 IS3 family transposase -
NUJ53_RS26410 (NUJ53_26410) 109700..110927 - 1228 Protein_129 IS3 family transposase -
NUJ53_RS26415 (NUJ53_26415) 111348..111830 - 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
NUJ53_RS26420 (NUJ53_26420) 111818..112084 - 267 WP_004213599.1 DUF1778 domain-containing protein Antitoxin
NUJ53_RS26425 (NUJ53_26425) 112279..112509 - 231 WP_004213598.1 hypothetical protein -
NUJ53_RS26430 (NUJ53_26430) 112523..112726 - 204 WP_004213596.1 HHA domain-containing protein -
NUJ53_RS26435 (NUJ53_26435) 112787..113280 - 494 Protein_134 DNA-binding protein -
NUJ53_RS26440 (NUJ53_26440) 113322..116291 - 2970 WP_004213592.1 Tn3 family transposase -
NUJ53_RS26445 (NUJ53_26445) 116294..116851 - 558 WP_004213590.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA / iroN / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA / rmpA2 1..235915 235915
- inside IScluster/Tn - - 109700..116851 7151


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T253668 WP_004098919.1 NZ_CP102439:c111830-111348 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10151.58 Da        Isoelectric Point: 4.5141

>AT253668 WP_004213599.1 NZ_CP102439:c112084-111818 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRVLIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure
AlphaFold DB A0A7D3T1D0

References