25366

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1472048..1472628 Replicon chromosome
Accession NC_015656
Organism Frankia symbiont of Datisca glomerata

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FSYMDG_RS06100 Protein ID WP_043603079.1
Coordinates 1472048..1472392 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FSYMDG_RS06105 Protein ID WP_043603082.1
Coordinates 1472386..1472628 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FSYMDG_RS06075 1467505..1468251 + 747 WP_013872712.1 MBL fold metallo-hydrolase -
FSYMDG_RS06080 1468671..1469474 + 804 WP_193353106.1 ribonuclease PH -
FSYMDG_RS06085 1469582..1470232 + 651 WP_050803714.1 RdgB/HAM1 family non-canonical purine NTP pyrophosphatase -
FSYMDG_RS06090 1470807..1471088 - 282 WP_013872715.1 hypothetical protein -
FSYMDG_RS24060 1471345..1471962 + 618 WP_013872716.1 TIGR03668 family PPOX class F420-dependent oxidoreductase -
FSYMDG_RS06100 1472048..1472392 - 345 WP_043603079.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FSYMDG_RS06105 1472386..1472628 - 243 WP_043603082.1 ribbon-helix-helix domain-containing protein Antitoxin
FSYMDG_RS06110 1472832..1474268 + 1437 WP_013872683.1 IS66 family transposase -
FSYMDG_RS06115 1474315..1474860 + 546 WP_050803351.1 hypothetical protein -
FSYMDG_RS06125 1474873..1476071 + 1199 Protein_1205 IS3 family transposase -
FSYMDG_RS06130 1476401..1476799 + 399 WP_013872720.1 DUF4326 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 11815.77 Da        Isoelectric Point: 11.3324

>T25366 WP_043603079.1 NC_015656:c1472392-1472048 [Candidatus Frankia datiscae]
MVIPRGAVHWADLGEPAGSRPAKHRPVLVVQATSYNASRLATVIAAVITSNTALATMPGNVFLPAAATGLPRDSVVNVTA
IVTLNKNELGRAVGTVPAGLMQEIDRGLRQVLAL

Download         Length: 345 bp

>T25366 NC_015656:c1472392-1472048 [Candidatus Frankia datiscae]
CTGGTGATCCCTCGCGGCGCTGTCCACTGGGCCGATCTCGGCGAGCCAGCGGGCAGCCGGCCGGCGAAGCACCGCCCAGT
GCTGGTCGTCCAGGCCACCTCCTACAACGCGAGCCGGCTGGCCACCGTCATCGCGGCCGTCATCACCTCGAACACGGCGC
TGGCCACCATGCCCGGCAACGTCTTCCTCCCAGCCGCCGCGACCGGCCTGCCCCGCGACTCCGTCGTCAACGTGACCGCC
ATCGTCACCCTCAACAAGAACGAGCTCGGGCGCGCCGTCGGCACCGTCCCGGCAGGCCTCATGCAGGAGATCGACCGGGG
ACTGCGACAAGTGCTCGCTCTCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8705.59 Da        Isoelectric Point: 4.3046

>AT25366 WP_043603082.1 NC_015656:c1472628-1472386 [Candidatus Frankia datiscae]
MKTAISIPDDTFDEVERHAVALGVSRSEFFTTAARHYLQKLDAQSLTERIDAALALAGPDDSSEAAVRAGRLTLDDGENW

Download         Length: 243 bp

>AT25366 NC_015656:c1472628-1472386 [Candidatus Frankia datiscae]
ATGAAAACTGCCATCTCGATCCCCGATGACACGTTCGACGAGGTCGAGCGCCACGCGGTCGCGCTCGGCGTGAGTCGTTC
GGAGTTCTTCACGACAGCAGCCCGCCACTACCTCCAGAAGCTCGATGCCCAGTCGCTGACCGAGCGCATCGACGCCGCAC
TCGCGCTCGCGGGCCCCGACGACTCGTCCGAGGCCGCGGTGCGCGCGGGCCGCCTGACCTTGGACGACGGCGAGAACTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References