Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 800946..801603 Replicon chromosome
Accession NZ_CP102438
Organism Klebsiella pneumoniae strain hvKP248

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NUJ53_RS03945 Protein ID WP_002916310.1
Coordinates 801193..801603 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NUJ53_RS03940 Protein ID WP_002916312.1
Coordinates 800946..801212 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ53_RS03915 (796154) 796154..797587 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NUJ53_RS03920 (797706) 797706..798434 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NUJ53_RS03925 (798484) 798484..798795 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NUJ53_RS03930 (798959) 798959..799618 + 660 WP_002916317.1 hemolysin III family protein -
NUJ53_RS03935 (799717) 799717..800700 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NUJ53_RS03940 (800946) 800946..801212 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NUJ53_RS03945 (801193) 801193..801603 + 411 WP_002916310.1 protein YgfX Toxin
NUJ53_RS03950 (801610) 801610..802131 - 522 WP_002916308.1 flavodoxin FldB -
NUJ53_RS03955 (802232) 802232..803128 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NUJ53_RS03960 (803151) 803151..803864 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NUJ53_RS03965 (803870) 803870..805603 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T253657 WP_002916310.1 NZ_CP102438:801193-801603 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT253657 WP_002916312.1 NZ_CP102438:800946-801212 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References