Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 201278..202017 Replicon chromosome
Accession NZ_CP102438
Organism Klebsiella pneumoniae strain hvKP248

Toxin (Protein)


Gene name tacT Uniprot ID A0A4U9WP91
Locus tag NUJ53_RS00985 Protein ID WP_004901283.1
Coordinates 201532..202017 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag NUJ53_RS00980 Protein ID WP_003026799.1
Coordinates 201278..201544 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ53_RS00965 (196782) 196782..198851 + 2070 WP_004901297.1 glycine--tRNA ligase subunit beta -
NUJ53_RS00970 (199147) 199147..200516 + 1370 WP_087661561.1 IS3 family transposase -
NUJ53_RS00975 (200717) 200717..201145 + 429 WP_004901287.1 GFA family protein -
NUJ53_RS00980 (201278) 201278..201544 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
NUJ53_RS00985 (201532) 201532..202017 + 486 WP_004901283.1 GNAT family N-acetyltransferase Toxin
NUJ53_RS00990 (202342) 202342..203388 - 1047 WP_022615678.1 IS481-like element ISKpn28 family transposase -
NUJ53_RS00995 (203462) 203462..203614 + 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
NUJ53_RS01000 (203916) 203916..205535 + 1620 WP_029884695.1 ATP-binding cassette domain-containing protein -
NUJ53_RS01005 (205634) 205634..205846 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NUJ53_RS01010 (206098) 206098..206388 - 291 WP_002921931.1 HTH-type transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 199884..203388 3504


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17594.32 Da        Isoelectric Point: 10.1788

>T253654 WP_004901283.1 NZ_CP102438:201532-202017 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLNQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT253654 WP_003026799.1 NZ_CP102438:201278-201544 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U9WP91

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References