Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 108107..109017 Replicon plasmid pK194-P1
Accession NZ_CP102436
Organism Klebsiella pneumoniae strain K194

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag NR799_RS25935 Protein ID WP_004026354.1
Coordinates 108107..108577 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag NR799_RS25940 Protein ID WP_004026357.1
Coordinates 108574..109017 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR799_RS25910 (NR799_25910) 103519..103917 - 399 WP_004212796.1 H-NS family nucleoid-associated regulatory protein -
NR799_RS25915 (NR799_25915) 104254..104748 - 495 WP_004212794.1 thermonuclease family protein -
NR799_RS25920 (NR799_25920) 104926..105192 + 267 WP_223175074.1 DUF1173 family protein -
NR799_RS25925 (NR799_25925) 105225..105875 + 651 WP_068893702.1 DUF1173 family protein -
NR799_RS25935 (NR799_25935) 108107..108577 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
NR799_RS25940 (NR799_25940) 108574..109017 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
NR799_RS25945 (NR799_25945) 109118..109621 - 504 Protein_117 DUF4113 domain-containing protein -
NR799_RS25950 (NR799_25950) 109719..109940 - 222 WP_004213643.1 DUF2188 domain-containing protein -
NR799_RS25955 (NR799_25955) 110121..110240 - 120 Protein_119 Fe3+-citrate ABC transporter substrate-binding protein -
NR799_RS25960 (NR799_25960) 110315..112441 - 2127 WP_004213640.1 TonB-dependent Fe(3+) dicitrate receptor FecA -
NR799_RS25965 (NR799_25965) 112528..113481 - 954 Protein_121 fec operon regulator FecR -
NR799_RS25970 (NR799_25970) 113478..113999 - 522 WP_004213635.1 ferric citrate uptake sigma factor FecI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..241781 241781


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T253646 WP_004026354.1 NZ_CP102436:c108577-108107 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT253646 WP_004026357.1 NZ_CP102436:c109017-108574 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References