Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4733127..4734808 Replicon chromosome
Accession NZ_CP102435
Organism Klebsiella pneumoniae strain K194

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NR799_RS23490 Protein ID WP_002885155.1
Coordinates 4733127..4734044 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NR799_RS23495 Protein ID WP_004151732.1
Coordinates 4734050..4734808 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR799_RS23470 (NR799_23470) 4728433..4729953 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NR799_RS23475 (NR799_23475) 4729950..4730948 + 999 WP_002885172.1 ribose ABC transporter permease -
NR799_RS23480 (NR799_23480) 4730979..4731920 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NR799_RS23485 (NR799_23485) 4731995..4733002 + 1008 WP_004151731.1 carbohydrate kinase family protein -
NR799_RS23490 (NR799_23490) 4733127..4734044 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NR799_RS23495 (NR799_23495) 4734050..4734808 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NR799_RS23500 (NR799_23500) 4734894..4735622 - 729 WP_002885152.1 response regulator transcription factor -
NR799_RS23505 (NR799_23505) 4735895..4738042 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NR799_RS23510 (NR799_23510) 4738272..4738958 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T253643 WP_002885155.1 NZ_CP102435:c4734044-4733127 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT253643 WP_004151732.1 NZ_CP102435:c4734808-4734050 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References