Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3917661..3918315 Replicon chromosome
Accession NZ_CP102435
Organism Klebsiella pneumoniae strain K194

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag NR799_RS19280 Protein ID WP_004144731.1
Coordinates 3917661..3918068 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NR799_RS19285 Protein ID WP_002916312.1
Coordinates 3918049..3918315 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR799_RS19260 (NR799_19260) 3913661..3915394 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
NR799_RS19265 (NR799_19265) 3915400..3916113 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NR799_RS19270 (NR799_19270) 3916136..3917032 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NR799_RS19275 (NR799_19275) 3917133..3917654 + 522 WP_002916308.1 flavodoxin FldB -
NR799_RS19280 (NR799_19280) 3917661..3918068 - 408 WP_004144731.1 protein YgfX Toxin
NR799_RS19285 (NR799_19285) 3918049..3918315 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NR799_RS19290 (NR799_19290) 3918561..3919544 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NR799_RS19295 (NR799_19295) 3919695..3920354 - 660 WP_002916317.1 hemolysin III family protein -
NR799_RS19300 (NR799_19300) 3920518..3920829 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
NR799_RS19305 (NR799_19305) 3920879..3921607 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NR799_RS19310 (NR799_19310) 3921726..3923159 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T253638 WP_004144731.1 NZ_CP102435:c3918068-3917661 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT253638 WP_002916312.1 NZ_CP102435:c3918315-3918049 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References