253627

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 84141..84739 Replicon plasmid unnamed2
Accession NZ_CP102430
Organism Pseudomonas psychrotolerans strain YY7

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag NRG74_RS24325 Protein ID WP_257706796.1
Coordinates 84141..84443 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A178LES3
Locus tag NRG74_RS24330 Protein ID WP_064308223.1
Coordinates 84440..84739 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRG74_RS24285 (NRG74_24285) 79172..79375 - 204 WP_257706790.1 hypothetical protein -
NRG74_RS24290 (NRG74_24290) 79385..79597 - 213 WP_074585490.1 hypothetical protein -
NRG74_RS24295 (NRG74_24295) 79681..81363 - 1683 WP_257706791.1 DNA cytosine methyltransferase -
NRG74_RS24300 (NRG74_24300) 81415..81657 - 243 WP_257706792.1 hypothetical protein -
NRG74_RS24305 (NRG74_24305) 81800..82891 - 1092 WP_257706793.1 hypothetical protein -
NRG74_RS24310 (NRG74_24310) 82952..83170 - 219 WP_257706794.1 hypothetical protein -
NRG74_RS24315 (NRG74_24315) 83225..83545 - 321 WP_257706807.1 theronine dehydrogenase -
NRG74_RS24320 (NRG74_24320) 83575..83943 - 369 WP_257706795.1 hypothetical protein -
NRG74_RS24325 (NRG74_24325) 84141..84443 + 303 WP_257706796.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NRG74_RS24330 (NRG74_24330) 84440..84739 + 300 WP_064308223.1 putative addiction module antidote protein Antitoxin
NRG74_RS24335 (NRG74_24335) 85668..86195 - 528 WP_257706797.1 hypothetical protein -
NRG74_RS24340 (NRG74_24340) 86246..86728 - 483 WP_257706798.1 helix-turn-helix domain-containing protein -
NRG74_RS24345 (NRG74_24345) 87219..87647 + 429 WP_257706799.1 S24 family peptidase -
NRG74_RS24350 (NRG74_24350) 87637..88923 + 1287 WP_257706800.1 Y-family DNA polymerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(6)-Id / aph(3'')-Ib - 1..98312 98312


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11194.80 Da        Isoelectric Point: 10.4673

>T253627 WP_257706796.1 NZ_CP102430:84141-84443 [Pseudomonas psychrotolerans]
MKTIKQTATFRNWERKLKDKQAKAIIAARVFRVANGLLGDVQPVGQGISELRIHHGPGYRVYFQQRGNQLVLLLCGGDKS
SQARDIETAKALASQWSDDE

Download         Length: 303 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10615.11 Da        Isoelectric Point: 4.7914

>AT253627 WP_064308223.1 NZ_CP102430:84440-84739 [Pseudomonas psychrotolerans]
MKEKIFDYDPADALTDPASIAVFLEDAFETGDAAYIAKALGVVARAKGMGEIAKESGLSRENLYRSFSENGNPTLKTMLA
VMQAVGLDLTARVHITPAH

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A178LES3

References