Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 20618..21255 Replicon plasmid unnamed1
Accession NZ_CP102429
Organism Pseudomonas psychrotolerans strain YY7

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NRG74_RS22630 Protein ID WP_068383192.1
Coordinates 20618..21028 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1H8Y3I8
Locus tag NRG74_RS22635 Protein ID WP_007162476.1
Coordinates 21025..21255 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRG74_RS22625 (NRG74_22625) 16384..20598 - 4215 WP_257706636.1 HEAT repeat domain-containing protein -
NRG74_RS22630 (NRG74_22630) 20618..21028 - 411 WP_068383192.1 type II toxin-antitoxin system VapC family toxin Toxin
NRG74_RS22635 (NRG74_22635) 21025..21255 - 231 WP_007162476.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NRG74_RS22640 (NRG74_22640) 21861..23051 - 1191 WP_257706771.1 Fic family protein -
NRG74_RS22645 (NRG74_22645) 23359..23613 + 255 WP_068383188.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
NRG74_RS22650 (NRG74_22650) 23610..23954 + 345 WP_257706637.1 hypothetical protein -
NRG74_RS22655 (NRG74_22655) 23964..24446 - 483 WP_068383184.1 hypothetical protein -
NRG74_RS22660 (NRG74_22660) 24443..25435 - 993 WP_257706638.1 DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3'')-Ib / aph(6)-Id - 1..245277 245277


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15116.52 Da        Isoelectric Point: 7.2152

>T253625 WP_068383192.1 NZ_CP102429:c21028-20618 [Pseudomonas psychrotolerans]
VTTYMLDTCICSFIMREHPDAVIRRLVAEVERGNRIVISAITYSEMRFGQIGKKASPKHKVLVDEFVRRLDAVIAWDLRA
VDATVEIMRQLNAAGTPIGSNDTAIAGHAIAIGCTLVTNNVREFSRVPGLVYEDWV

Download         Length: 411 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8452.58 Da        Isoelectric Point: 4.5203

>AT253625 WP_007162476.1 NZ_CP102429:c21255-21025 [Pseudomonas psychrotolerans]
MRTVSIFMNGRNQAVRLPQDMAFEGIGELEISKEGDVITLRPARPSWTSLAELPKADADFLQERTAVASDEGRFTL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1H8Y3I8

References