253624

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 982..1456 Replicon plasmid p6
Accession NZ_CP102396
Organism Klebsiella pneumoniae strain K64

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag NRF21_RS29520 Protein ID WP_004197762.1
Coordinates 1190..1456 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag NRF21_RS29515 Protein ID WP_000879771.1
Coordinates 982..1206 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRF21_RS29510 (NRF21_29510) 103..315 + 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
NRF21_RS29515 (NRF21_29515) 982..1206 + 225 WP_000879771.1 DUF6290 family protein Antitoxin
NRF21_RS29520 (NRF21_29520) 1190..1456 + 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NRF21_RS29525 (NRF21_29525) 1526..1876 - 351 WP_004197756.1 hypothetical protein -
NRF21_RS29530 (NRF21_29530) 1942..2487 - 546 WP_023317533.1 hypothetical protein -
NRF21_RS29535 (NRF21_29535) 2513..2839 - 327 WP_050516389.1 hypothetical protein -
NRF21_RS29540 (NRF21_29540) 3995..4171 + 177 WP_004197757.1 hypothetical protein -
NRF21_RS29545 (NRF21_29545) 4161..4505 + 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
NRF21_RS29550 (NRF21_29550) 4714..5148 + 435 Protein_9 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T253624 WP_004197762.1 NZ_CP102396:1190-1456 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT253624 WP_000879771.1 NZ_CP102396:982-1206 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References