Detailed information of TA system TA025362

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 949247..950208
• Replicon: chromosome
• Accession: NC_015637
• Organism: Vibrio anguillarum 775

Toxin (Protein)

• Gene name: -
• Uniprot ID: F7YRB7
• Locus tag: VAA_RS18105
• Protein ID: WP_013868567.1
• Coordinates: 949247..949780 (-)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: VAA_RS19205
• Protein ID: WP_013868568.1
• Coordinates: 949777..950208 (-)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VAA_RS18720	944676..944846	-	171	Protein_812	pentapeptide repeat-containing protein	-
VAA_RS18085	945741..946397	-	657	WP_013868559.1	hypothetical protein	-
VAA_RS18730	946437..946553	-	117	WP_080749045.1	DUF3265 domain-containing protein	-
VAA_RS18090	946550..946894	-	345	WP_013868560.1	hypothetical protein	-
VAA_RS18095	947045..947593	-	549	WP_019281391.1	hypothetical protein	-
VAA_RS18735	947647..947772	-	126	WP_013868562.1	DUF3265 domain-containing protein	-
VAA_RS18100	948280..948561	-	282	WP_029190024.1	hypothetical protein	-
VAA_RS18105	949247..949780	-	534	WP_013868567.1	GNAT family N-acetyltransferase	Toxin
VAA_RS19205	949777..950208	-	432	WP_013868568.1	DUF1778 domain-containing protein	Antitoxin
VAA_RS18115	950727..951242	-	516	WP_013868571.1	GNAT family N-acetyltransferase	-
VAA_RS18750	951280..951372	-	93	WP_072600976.1	DUF3265 domain-containing protein	-
VAA_RS18990	951487..951570	+	84	Protein_823	helix-turn-helix domain-containing protein	-
VAA_RS18120	951601..952035	+	435	WP_011154684.1	recombination regulator RecX	-
VAA_RS18755	952325..952417	+	93	WP_193386251.1	DUF3265 domain-containing protein	-
VAA_RS18130	953179..953421	-	243	WP_019281433.1	hypothetical protein	-
VAA_RS18355	953408..953857	-	450	WP_013868575.1	hypothetical protein	-
VAA_RS18145	954274..954783	+	510	WP_013868576.1	ATPase AAA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	930919..987961	57042
	-	inside	Integron	qnrVC6	-	934167..944846	10679
	-	inside	Integron	-	-	945057..951392	6335

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (59-135)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20222.47 Da
• Isoelectric Point: 9.1188

>T25362 WP_013868567.1 NC_015637:c949780-949247 [Vibrio anguillarum 775]
VSWGREFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSGQPLLNQKFAICAFYSVAPSSISRETLPT
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMYLPMKTVEQLFNQ

Nucleotide

• Length: 534 bp

>T25362 NC_015637:c949780-949247 [Vibrio anguillarum 775]
GTGAGTTGGGGCAGAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGGTCAAC
CGCTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGACA
CAGTTAGCAAAGAAACTACCGAGATATCCAATCCCTGTTTTTCTGTTGGCTCAATTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATTCGTGCGCTGAAGTACTTGTGGGAAGTAAATCATCACATGAGGGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTACTTACCGATGAAAACGGTAGAACAGCTTTTTAATCAATAG

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 15859.40 Da
• Isoelectric Point: 7.0831

>AT25362 WP_013868568.1 NC_015637:c950208-949777 [Vibrio anguillarum 775]
VFTVCFLSSAVRCQPLSRALYSPSFRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLG
LKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Nucleotide

• Length: 432 bp

>AT25362 NC_015637:c950208-949777 [Vibrio anguillarum 775]
GTGTTTACAGTGTGTTTTTTGAGTTCGGCGGTGCGTTGTCAACCCCTTAGCCGGGCGTTATATTCTCCCTCGTTCCGTAA
ACTTTCCGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTATGCAGGAGGGG
TTATGGCAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGC
TTAAAAAGTCTCACTGAATACGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTAT
GGTTAAAGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTG
TTAAATTTACAGAGAAGAGCGGTATCAAGTGA

Structures

Toxin

• AlphaFold DB: A0A241NLG3