Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 118664..119334 | Replicon | plasmid pVir-1 |
Accession | NZ_CP102391 | ||
Organism | Klebsiella pneumoniae strain K64 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | Q6U619 |
Locus tag | NRF21_RS27130 | Protein ID | WP_004213072.1 |
Coordinates | 118664..119107 (-) | Length | 148 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | Q6U620 |
Locus tag | NRF21_RS27135 | Protein ID | WP_004213073.1 |
Coordinates | 119104..119334 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NRF21_RS27095 (NRF21_27095) | 114075..114350 | + | 276 | WP_004213932.1 | carboxymuconolactone decarboxylase family protein | - |
NRF21_RS27100 (NRF21_27100) | 114413..114904 | + | 492 | WP_011251327.1 | DM13 domain-containing protein | - |
NRF21_RS27105 (NRF21_27105) | 114953..115873 | + | 921 | WP_004213934.1 | DUF1471 domain-containing protein | - |
NRF21_RS27110 (NRF21_27110) | 115964..116367 | + | 404 | Protein_135 | GAF domain-containing protein | - |
NRF21_RS27115 (NRF21_27115) | 116885..117520 | - | 636 | Protein_136 | mucoid phenotype regulator RmpA2 | - |
NRF21_RS27120 (NRF21_27120) | 117937..118241 | + | 305 | Protein_137 | transposase | - |
NRF21_RS27125 (NRF21_27125) | 118264..118515 | - | 252 | WP_186987481.1 | hypothetical protein | - |
NRF21_RS27130 (NRF21_27130) | 118664..119107 | - | 444 | WP_004213072.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
NRF21_RS27135 (NRF21_27135) | 119104..119334 | - | 231 | WP_004213073.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
NRF21_RS27140 (NRF21_27140) | 119942..121075 | + | 1134 | WP_004213075.1 | DUF3800 domain-containing protein | - |
NRF21_RS27145 (NRF21_27145) | 121091..121384 | + | 294 | WP_004213076.1 | hypothetical protein | - |
NRF21_RS27150 (NRF21_27150) | 121374..121580 | - | 207 | WP_004213077.1 | hypothetical protein | - |
NRF21_RS27155 (NRF21_27155) | 121932..122222 | + | 291 | WP_004213078.1 | hypothetical protein | - |
NRF21_RS27160 (NRF21_27160) | 122212..123111 | + | 900 | WP_004225022.1 | nucleotide-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | - | iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..193821 | 193821 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T253617 WP_004213072.1 NZ_CP102391:c119107-118664 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
Download Length: 444 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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