Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /RES-TIGR02293 |
Location | 78601..79511 | Replicon | plasmid pVir-1 |
Accession | NZ_CP102391 | ||
Organism | Klebsiella pneumoniae strain K64 |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A663AYG0 |
Locus tag | NRF21_RS26885 | Protein ID | WP_004026354.1 |
Coordinates | 78601..79071 (-) | Length | 157 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A6P1V3Q9 |
Locus tag | NRF21_RS26890 | Protein ID | WP_004026357.1 |
Coordinates | 79068..79511 (-) | Length | 148 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NRF21_RS26845 (NRF21_26845) | 73917..74231 | + | 315 | WP_011251273.1 | hypothetical protein | - |
NRF21_RS26850 (NRF21_26850) | 74240..74734 | + | 495 | WP_011251274.1 | hypothetical protein | - |
NRF21_RS26855 (NRF21_26855) | 74740..75180 | + | 441 | WP_011251275.1 | hypothetical protein | - |
NRF21_RS26860 (NRF21_26860) | 75605..76561 | - | 957 | WP_011251280.1 | DsbA family protein | - |
NRF21_RS26865 (NRF21_26865) | 76621..76962 | - | 342 | WP_011251281.1 | hypothetical protein | - |
NRF21_RS26870 (NRF21_26870) | 76976..77287 | - | 312 | WP_011251282.1 | hypothetical protein | - |
NRF21_RS26875 (NRF21_26875) | 77304..77753 | - | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
NRF21_RS26885 (NRF21_26885) | 78601..79071 | - | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
NRF21_RS26890 (NRF21_26890) | 79068..79511 | - | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
NRF21_RS26895 (NRF21_26895) | 79612..80115 | - | 504 | Protein_92 | DUF4113 domain-containing protein | - |
NRF21_RS26900 (NRF21_26900) | 80321..81301 | - | 981 | WP_000019473.1 | IS5-like element ISKpn26 family transposase | - |
NRF21_RS26905 (NRF21_26905) | 81367..82674 | + | 1308 | Protein_94 | FepA family TonB-dependent siderophore receptor | - |
NRF21_RS26910 (NRF21_26910) | 82736..82957 | + | 222 | WP_004213615.1 | hypothetical protein | - |
NRF21_RS26915 (NRF21_26915) | 83100..84002 | - | 903 | WP_004213613.1 | DMT family inner membrane transporter PEG344 | - |
NRF21_RS26920 (NRF21_26920) | 84075..84476 | - | 402 | WP_214588034.1 | LuxR C-terminal-related transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | - | iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..193821 | 193821 | |
- | inside | IScluster/Tn | - | iroN / rmpA | 72320..92296 | 19976 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T253616 WP_004026354.1 NZ_CP102391:c79071-78601 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT253616 WP_004026357.1 NZ_CP102391:c79511-79068 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A663AYG0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6P1V3Q9 |