Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4792363..4792879 Replicon chromosome
Accession NZ_CP102390
Organism Klebsiella pneumoniae strain K64

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NRF21_RS23760 Protein ID WP_002886902.1
Coordinates 4792363..4792647 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NRF21_RS23765 Protein ID WP_002886901.1
Coordinates 4792637..4792879 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRF21_RS23735 (NRF21_23735) 4787847..4788110 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NRF21_RS23740 (NRF21_23740) 4788240..4788413 + 174 WP_002886906.1 hypothetical protein -
NRF21_RS23745 (NRF21_23745) 4788416..4789159 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NRF21_RS23750 (NRF21_23750) 4789516..4791654 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
NRF21_RS23755 (NRF21_23755) 4791895..4792359 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NRF21_RS23760 (NRF21_23760) 4792363..4792647 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NRF21_RS23765 (NRF21_23765) 4792637..4792879 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NRF21_RS23770 (NRF21_23770) 4792957..4794867 - 1911 WP_004152270.1 PRD domain-containing protein -
NRF21_RS23775 (NRF21_23775) 4794890..4796044 - 1155 WP_002886900.1 lactonase family protein -
NRF21_RS23780 (NRF21_23780) 4796110..4796850 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T253612 WP_002886902.1 NZ_CP102390:c4792647-4792363 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT253612 WP_002886901.1 NZ_CP102390:c4792879-4792637 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References