Detailed information of TA system TA025361

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 943478..944006
• Replicon: chromosome
• Accession: NC_015637
• Organism: Vibrio anguillarum 775

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F7YRA6
• Locus tag: VAA_RS18080
• Protein ID: WP_013868556.1
• Coordinates: 943719..944006 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F7YRA5
• Locus tag: VAA_RS18075
• Protein ID: WP_013868555.1
• Coordinates: 943478..943729 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VAA_RS19200	938706..938981	+	276	WP_013868550.1	hypothetical protein	-
VAA_RS18060	939340..940883	-	1544	Protein_805	IS66 family transposase	-
VAA_RS18955	940943..941116	-	174	Protein_806	IS66 family insertion sequence element accessory protein TnpB	-
VAA_RS18710	941295..941613	-	319	Protein_807	IS66 family insertion sequence element accessory protein TnpB	-
VAA_RS18065	941711..942532	-	822	Protein_808	IS30 family transposase	-
VAA_RS18070	942779..943264	+	486	WP_107489895.1	hypothetical protein	-
VAA_RS18075	943478..943729	+	252	WP_013868555.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
VAA_RS18080	943719..944006	+	288	WP_013868556.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VAA_RS18720	944676..944846	-	171	Protein_812	pentapeptide repeat-containing protein	-
VAA_RS18085	945741..946397	-	657	WP_013868559.1	hypothetical protein	-
VAA_RS18730	946437..946553	-	117	WP_080749045.1	DUF3265 domain-containing protein	-
VAA_RS18090	946550..946894	-	345	WP_013868560.1	hypothetical protein	-
VAA_RS18095	947045..947593	-	549	WP_019281391.1	hypothetical protein	-
VAA_RS18735	947647..947772	-	126	WP_013868562.1	DUF3265 domain-containing protein	-
VAA_RS18100	948280..948561	-	282	WP_029190024.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	930919..987961	57042
	-	inside	Integron	qnrVC6	-	934167..944846	10679
	-	inside	Integron	-	-	945057..951392	6335

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (11-70)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11064.07 Da
• Isoelectric Point: 10.5506

>T25361 WP_013868556.1 NC_015637:943719-944006 [Vibrio anguillarum 775]
MTYKLKFLPAAKKEWSKLAPPIQSQFKKKLKERLENPHVPSSKLRGYDSVYKIKLRTAGYRLAYEVIDDEIVVYVLAIGK
RDKDAVYKKLASRFS

Nucleotide

• Length: 288 bp

>T25361 NC_015637:943719-944006 [Vibrio anguillarum 775]
ATGACTTATAAGCTAAAATTTCTACCGGCTGCCAAGAAAGAGTGGAGTAAGTTAGCTCCACCAATTCAAAGTCAGTTCAA
AAAGAAGCTTAAAGAGCGTCTGGAAAACCCGCATGTTCCTTCTTCTAAACTGCGTGGCTATGACTCAGTTTATAAGATCA
AACTACGTACAGCAGGCTATCGCTTAGCCTATGAAGTCATTGATGATGAAATCGTGGTGTACGTGTTAGCTATTGGAAAA
CGAGATAAAGATGCAGTGTACAAAAAGTTAGCATCAAGGTTCTCGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9154.36 Da
• Isoelectric Point: 4.0414

>AT25361 WP_013868555.1 NC_015637:943478-943729 [Vibrio anguillarum 775]
MRQVLADCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEFLMDMLDDYELAKLVESRRGELSEAVEVNI
DDL

Nucleotide

• Length: 252 bp

>AT25361 NC_015637:943478-943729 [Vibrio anguillarum 775]
ATGAGACAGGTTTTAGCTGATTGTTCTGCAAGTATTTCTGAGTTAAAGAAAAATCCAACCGCTTTACTAAACGAAGCTGA
TGGTTCTGCCATTGCTATTCTAAACCACAATAAGCCAGCAGCTTATCTTGTCCCAGCAGAAACTTATGAGTTTCTAATGG
ATATGCTCGATGACTATGAGCTTGCTAAACTAGTTGAAAGTCGCCGTGGTGAATTGTCTGAAGCGGTGGAAGTAAATATC
GATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A1E5BHG0

Antitoxin

• AlphaFold DB: A0A7X8TZB8