Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2733541..2735129 Replicon chromosome
Accession NZ_CP102390
Organism Klebsiella pneumoniae strain K64

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag NRF21_RS13605 Protein ID WP_004199851.1
Coordinates 2733541..2734863 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NRF21_RS13610 Protein ID WP_002904790.1
Coordinates 2734863..2735129 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRF21_RS13590 (NRF21_13590) 2728606..2731107 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
NRF21_RS13595 (NRF21_13595) 2731095..2732099 + 1005 WP_004199852.1 fimbrial protein -
NRF21_RS13600 (NRF21_13600) 2732232..2733524 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NRF21_RS13605 (NRF21_13605) 2733541..2734863 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
NRF21_RS13610 (NRF21_13610) 2734863..2735129 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NRF21_RS13615 (NRF21_13615) 2735395..2735721 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NRF21_RS13620 (NRF21_13620) 2735718..2736218 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NRF21_RS13625 (NRF21_13625) 2736196..2737575 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
NRF21_RS13630 (NRF21_13630) 2737921..2739075 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NRF21_RS13635 (NRF21_13635) 2739056..2739979 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T253609 WP_004199851.1 NZ_CP102390:c2734863-2733541 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT253609 WP_002904790.1 NZ_CP102390:c2735129-2734863 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References