Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 884582..885236 Replicon chromosome
Accession NZ_CP102390
Organism Klebsiella pneumoniae strain K64

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag NRF21_RS04475 Protein ID WP_004144731.1
Coordinates 884829..885236 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NRF21_RS04470 Protein ID WP_002916312.1
Coordinates 884582..884848 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRF21_RS04445 (NRF21_04445) 879738..881171 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NRF21_RS04450 (NRF21_04450) 881290..882018 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NRF21_RS04455 (NRF21_04455) 882068..882379 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
NRF21_RS04460 (NRF21_04460) 882543..883202 + 660 WP_002916317.1 hemolysin III family protein -
NRF21_RS04465 (NRF21_04465) 883353..884336 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NRF21_RS04470 (NRF21_04470) 884582..884848 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NRF21_RS04475 (NRF21_04475) 884829..885236 + 408 WP_004144731.1 protein YgfX Toxin
NRF21_RS04480 (NRF21_04480) 885243..885764 - 522 WP_002916308.1 flavodoxin FldB -
NRF21_RS04485 (NRF21_04485) 885865..886761 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NRF21_RS04490 (NRF21_04490) 886784..887497 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NRF21_RS04495 (NRF21_04495) 887503..889236 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T253604 WP_004144731.1 NZ_CP102390:884829-885236 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT253604 WP_002916312.1 NZ_CP102390:884582-884848 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References