Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 262..959 Replicon plasmid pDB-4
Accession NZ_CP102388
Organism Sphingopyxis sp. DBS4

Toxin (Protein)


Gene name tad Uniprot ID T0J3S2
Locus tag NP825_RS23055 Protein ID WP_013041565.1
Coordinates 262..636 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID T0G937
Locus tag NP825_RS23060 Protein ID WP_006964370.1
Coordinates 633..959 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP825_RS23055 262..636 + 375 WP_013041565.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NP825_RS23060 633..959 + 327 WP_006964370.1 helix-turn-helix transcriptional regulator Antitoxin
NP825_RS23065 959..1201 + 243 WP_013041566.1 hypothetical protein -
NP825_RS23070 1194..1493 + 300 WP_013041567.1 hypothetical protein -
NP825_RS23075 1514..2626 - 1113 WP_145206862.1 muramidase -
NP825_RS23080 2629..4344 - 1716 WP_030092735.1 P-type conjugative transfer protein TrbL -
NP825_RS23085 4355..4597 - 243 WP_145206861.1 EexN family lipoprotein -
NP825_RS23090 4607..5362 - 756 WP_022675885.1 P-type conjugative transfer protein TrbJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..84199 84199


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-108)

Antitoxin

HigA2-like, helix-turn-helix domain

(15-94)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13960.67 Da        Isoelectric Point: 9.4885

>T253600 WP_013041565.1 NZ_CP102388:262-636 [Sphingopyxis sp. DBS4]
MDTERPVRWVASSKRDFREFPDDVQDVMGYALHLAQQGGQHASTKPLKGFGGAGVVEIIDDHQGDTFRTVYTVKFAEAVY
VLHAFQKKSKQGKATPQADMDLIRTRLKSAEEHHRQHQTPRGTA

Download         Length: 375 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11792.57 Da        Isoelectric Point: 7.1681

>AT253600 WP_006964370.1 NZ_CP102388:633-959 [Sphingopyxis sp. DBS4]
MSAQDEIIEEGSGNVFADLGFADPDTHLLKAQLVTRVAEAMQERKLTQIAAAKVTGSTQPELSRILRGQFRSVSVERLLA
MLTRLGCKVDIVVRPQGRTTESAVIHFA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J7XHG4

Antitoxin

Source ID Structure
AlphaFold DB A0A0J8A803

References