Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 9693..10459 Replicon chromosome
Accession NC_015637
Organism Vibrio anguillarum 775

Toxin (Protein)


Gene name - Uniprot ID F7YRS3
Locus tag VAA_RS14095 Protein ID WP_013867769.1
Coordinates 9693..10190 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID F7YRS4
Locus tag VAA_RS14100 Protein ID WP_013867770.1
Coordinates 10187..10459 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VAA_RS14070 6162..6515 - 354 WP_011154649.1 IS66 family insertion sequence element accessory protein TnpB -
VAA_RS14075 6512..6829 - 318 WP_011154648.1 IS66 family insertion sequence hypothetical protein -
VAA_RS18610 6944..7036 + 93 WP_194291283.1 DUF3265 domain-containing protein -
VAA_RS18615 7124..7330 + 207 WP_013867765.1 DUF1289 domain-containing protein -
VAA_RS14080 7450..7680 - 231 WP_013867766.1 PAS factor family protein -
VAA_RS14085 7974..8210 - 237 WP_013867767.1 hypothetical protein -
VAA_RS14090 8495..8983 + 489 WP_013867768.1 hypothetical protein -
VAA_RS18945 8974..9105 + 132 Protein_12 DUF3265 domain-containing protein -
VAA_RS14095 9693..10190 - 498 WP_013867769.1 GNAT family N-acetyltransferase Toxin
VAA_RS14100 10187..10459 - 273 WP_013867770.1 DUF1778 domain-containing protein Antitoxin
VAA_RS14110 11210..11929 + 720 Protein_15 hypothetical protein -
VAA_RS14115 11986..12906 - 921 WP_011154643.1 IS5-like element ISVa2 family transposase -
VAA_RS14120 13005..13298 + 294 WP_020977843.1 potassium channel family protein -
VAA_RS14125 13571..13960 + 390 WP_019280976.1 DUF1090 domain-containing protein -
VAA_RS18625 13964..14053 + 90 WP_019280977.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 6512..13960 7448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18525.25 Da        Isoelectric Point: 9.2555

>T25360 WP_013867769.1 NC_015637:c10190-9693 [Vibrio anguillarum 775]
MMNTVLLDKVKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSSHIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKYFYERYGFQAFQDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T25360 NC_015637:c10190-9693 [Vibrio anguillarum 775]
ATGATGAATACGGTACTTTTAGATAAAGTTAAACACGATAGAAACCGATTCAACTGTGGTATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAAGACAACACCAGAACGTTTGTTCTGGAAGATGATAACAACAGCTCAC
ATATCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCCGATAAATTACAAAAAAAGCACCAA
TCATCCACCTCTGGTGGCCTAATTGCCCGTCTTGCTGTCGATGACAGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
CATCGATGCACTCAGAAAGCTATTAGCTGCTAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGTG
CAAAATATTTTTATGAACGCTATGGCTTTCAGGCATTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCGGATGTA
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9731.18 Da        Isoelectric Point: 8.6154

>AT25360 WP_013867770.1 NC_015637:c10459-10187 [Vibrio anguillarum 775]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAILLMDALDRPTAQNSKLRA
ASERYESKAQ

Download         Length: 273 bp

>AT25360 NC_015637:c10459-10187 [Vibrio anguillarum 775]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGATTTACTCACTAAAGCTGCCGCTATCGC
TGGTATGTCTAGTATTAACTCATTTGTTCTAAGCGCTGCAATTGAAAAGGCTAAACAAGTCATCGAACGTGAGCAAGCTT
TAAAACTGAGCCAAGCCGATGCGATTTTGCTGATGGACGCATTAGACCGCCCAACAGCACAGAACTCAAAACTAAGAGCG
GCCTCTGAACGATACGAGAGCAAGGCTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y3QZT4

Antitoxin

Source ID Structure
AlphaFold DB A0A7X8U164

References