Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 77490..78166 Replicon plasmid pDB-2
Accession NZ_CP102386
Organism Sphingopyxis sp. DBS4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NP825_RS22040 Protein ID WP_257551804.1
Coordinates 77490..77903 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NP825_RS22045 Protein ID WP_257551805.1
Coordinates 77900..78166 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP825_RS22000 72602..72886 - 285 WP_257551797.1 hypothetical protein -
NP825_RS22005 72898..73593 - 696 WP_257551798.1 hypothetical protein -
NP825_RS22010 73914..74585 + 672 WP_257551799.1 hypothetical protein -
NP825_RS22015 74578..75450 + 873 WP_257551800.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
NP825_RS22020 75590..75895 - 306 WP_257551801.1 hypothetical protein -
NP825_RS22025 75900..76289 - 390 WP_257551802.1 hypothetical protein -
NP825_RS22030 76294..76767 - 474 WP_257551803.1 hypothetical protein -
NP825_RS22035 76764..77282 - 519 WP_020818772.1 hypothetical protein -
NP825_RS22040 77490..77903 - 414 WP_257551804.1 type II toxin-antitoxin system VapC family toxin Toxin
NP825_RS22045 77900..78166 - 267 WP_257551805.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NP825_RS22050 78351..78815 - 465 WP_257551806.1 DUF736 domain-containing protein -
NP825_RS22055 79041..80696 - 1656 WP_257551807.1 ATP-binding protein -
NP825_RS22060 80781..81134 - 354 WP_257551808.1 DUF3768 domain-containing protein -
NP825_RS22065 81131..82109 - 979 Protein_84 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..227036 227036


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(17-54)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14601.68 Da        Isoelectric Point: 4.4056

>T253598 WP_257551804.1 NZ_CP102386:c77903-77490 [Sphingopyxis sp. DBS4]
VSGLYMLDTNTVSELARNPQGSVAARVAEVGPDAICVSIITAAELRYGCARAGSPRLLAQIEAILDSLQILALDVPADTE
YAGIRAELEAAGKPIGPNDWFIAAHAYALEAVLVTANITDFSRIRALKVENWITDLH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9934.63 Da        Isoelectric Point: 10.0843

>AT253598 WP_257551805.1 NZ_CP102386:c78166-77900 [Sphingopyxis sp. DBS4]
MARKKAVSVPPREAKLFRNNKSQALRIPADFELPGDRVMIHRDGERLIIEPVRRKNLLEVLASLQPLGPDDQFPDVEGTL
LPIKAIDL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References