Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 3293681..3295196 Replicon chromosome
Accession NZ_CP102384
Organism Sphingopyxis sp. DBS4

Toxin (Protein)


Gene name rlegT Uniprot ID A0A095B2N2
Locus tag NP825_RS15840 Protein ID WP_037556217.1
Coordinates 3294291..3295196 (+) Length 302 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID A0A095D9J0
Locus tag NP825_RS15835 Protein ID WP_037556215.1
Coordinates 3293681..3294298 (+) Length 206 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP825_RS15800 3289460..3290920 - 1461 Protein_3112 ParB N-terminal domain-containing protein -
NP825_RS15805 3291045..3291446 - 402 WP_037556205.1 DUF2958 domain-containing protein -
NP825_RS15810 3291681..3291872 + 192 WP_037556207.1 hypothetical protein -
NP825_RS15815 3291874..3292203 + 330 WP_037556209.1 hypothetical protein -
NP825_RS15820 3292215..3292727 + 513 WP_037556211.1 hypothetical protein -
NP825_RS15825 3292756..3293403 + 648 WP_037556213.1 SOS response-associated peptidase family protein -
NP825_RS15830 3293426..3293551 - 126 WP_257545241.1 hypothetical protein -
NP825_RS15835 3293681..3294298 + 618 WP_037556215.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
NP825_RS15840 3294291..3295196 + 906 WP_037556217.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NP825_RS15845 3295475..3296230 + 756 WP_231729159.1 LuxR family transcriptional regulator -
NP825_RS15850 3296330..3296908 + 579 WP_257545246.1 acyl-homoserine-lactone synthase -
NP825_RS15855 3296892..3299039 + 2148 WP_197412310.1 prolyl oligopeptidase family serine peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3151980..3301595 149615


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-265)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(18-55)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 32734.43 Da        Isoelectric Point: 4.4399

>T253597 WP_037556217.1 NZ_CP102384:3294291-3295196 [Sphingopyxis sp. DBS4]
MAKAPVNLAASVKDRLLQLARKERQPFDVLLVRFALERLLYRLSLSPLRDQFILKGGLLVTLWLEDDNRVTRDADFLAFG
DASAERLIADFGAIMKIEAADGLTFDIDALTARPIREGAEYGGMRLTTTAFLERTRIPITIDLGFGDALSDPAPPTSFAT
LLDFPDPEIRTYSPTSVIAEKFQAMVALGIANGRMKDFYDLWAIPQACDINAQALDAALAATFDRRGTPIPADRPPGLSA
AMFEDGDKRRQWDAYAASLELEGVTFSAVIDAVWGLVAPSCERLLAHDVSIATSTPDAAGA

Download         Length: 906 bp

Antitoxin


Download         Length: 206 a.a.        Molecular weight: 22367.72 Da        Isoelectric Point: 9.9799

>AT253597 WP_037556215.1 NZ_CP102384:3293681-3294298 [Sphingopyxis sp. DBS4]
MHTSITQGETLRALFGAHPILRARELRAAGVAPETIARAVDSGDIDRIARGLYQLHGAPIDTDQGLAEITKRIPNGVIAM
VSALAFHGLTDQMPRRVWVAIGPSDWAPVIDYPPVRIVRLADKYRRQGIEHHKVAGVDVPIYSVPKTLADLFRNPRLVDR
SVAVESLRAALDQRKTSPGDIAEAAAAGGVWKRMQPYLEALSFNG

Download         Length: 618 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A095B2N2

Antitoxin

Source ID Structure
AlphaFold DB A0A095D9J0

References