Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 3022695..3023398 Replicon chromosome
Accession NZ_CP102384
Organism Sphingopyxis sp. DBS4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NP825_RS14440 Protein ID WP_257544735.1
Coordinates 3022964..3023398 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NP825_RS14435 Protein ID WP_257544733.1
Coordinates 3022695..3022967 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP825_RS14405 3018578..3019090 - 513 WP_257544721.1 sigma-70 family RNA polymerase sigma factor -
NP825_RS14410 3019087..3019581 - 495 WP_257544723.1 hypothetical protein -
NP825_RS14415 3019964..3020605 + 642 WP_257544725.1 hypothetical protein -
NP825_RS14420 3020872..3021792 - 921 WP_257544727.1 HEPN domain-containing protein -
NP825_RS14425 3022221..3022451 + 231 WP_257544729.1 AlpA family phage regulatory protein -
NP825_RS14430 3022453..3022635 + 183 WP_257544731.1 hypothetical protein -
NP825_RS14435 3022695..3022967 + 273 WP_257544733.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NP825_RS14440 3022964..3023398 + 435 WP_257544735.1 type II toxin-antitoxin system VapC family toxin Toxin
NP825_RS14445 3023395..3025029 + 1635 WP_257544737.1 recombinase family protein -
NP825_RS14450 3025125..3026009 - 885 WP_257544739.1 metal-dependent hydrolase -
NP825_RS14455 3026088..3026675 + 588 WP_257544741.1 TetR/AcrR family transcriptional regulator -
NP825_RS14460 3026855..3027898 + 1044 WP_257544743.1 GTPase ObgE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-64)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15836.96 Da        Isoelectric Point: 4.7636

>T253596 WP_257544735.1 NZ_CP102384:3022964-3023398 [Sphingopyxis sp. DBS4]
VSFLLDTNVISEGAKPRPDAGVMDWLASIDEEQLHLSIVSLAELRHGVERLDAGRRKTALDNWLTEQLPLRFDDRLLPVD
AETADAWGRIVAAAQAVGRPIGAMDAFIAAAAKRHQLTLVTRNVVDFEATGIRLFNPWSQGDQP

Download         Length: 435 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9900.33 Da        Isoelectric Point: 8.7461

>AT253596 WP_257544733.1 NZ_CP102384:3022695-3022967 [Sphingopyxis sp. DBS4]
MNAEIPSDTWTVAQAKAKLSEVIDKARRKGPQAITRNGKSAVVVVDAELWEKTQRREMMGSFADFILASPLRGSGLEVER
LEGGIRETSL

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References