253590

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4325840..4326435 Replicon chromosome
Accession NZ_CP102380
Organism Escherichia coli strain BM28

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag NR349_RS20950 Protein ID WP_000239577.1
Coordinates 4326085..4326435 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NR349_RS20945 Protein ID WP_001223208.1
Coordinates 4325840..4326091 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR349_RS20935 (4321505) 4321505..4325284 + 3780 WP_262515045.1 autotransporter assembly complex protein TamB -
NR349_RS20940 (4325287) 4325287..4325628 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NR349_RS20945 (4325840) 4325840..4326091 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NR349_RS20950 (4326085) 4326085..4326435 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
NR349_RS20955 (4326515) 4326515..4327045 - 531 WP_000055075.1 inorganic diphosphatase -
NR349_RS20960 (4327355) 4327355..4328311 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NR349_RS20965 (4328451) 4328451..4329953 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
NR349_RS20970 (4329967) 4329967..4330989 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T253590 WP_000239577.1 NZ_CP102380:4326085-4326435 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT253590 WP_001223208.1 NZ_CP102380:4325840-4326091 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References