Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2648220..2648887 Replicon chromosome
Accession NZ_CP102380
Organism Escherichia coli strain BM28

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag NR349_RS12940 Protein ID WP_001094400.1
Coordinates 2648558..2648887 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag NR349_RS12935 Protein ID WP_000072690.1
Coordinates 2648220..2648537 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR349_RS12905 (2643272) 2643272..2644281 - 1010 Protein_2520 arsenic transporter -
NR349_RS12910 (2644423) 2644423..2646126 + 1704 WP_000896263.1 protein YfjW -
NR349_RS12915 (2646698) 2646698..2646921 + 224 Protein_2522 DUF905 domain-containing protein -
NR349_RS12920 (2647024) 2647024..2647482 + 459 WP_000211841.1 antirestriction protein -
NR349_RS12925 (2647491) 2647491..2647973 + 483 WP_001407480.1 RadC family protein -
NR349_RS12930 (2647982) 2647982..2648182 + 201 WP_001395452.1 DUF987 domain-containing protein -
NR349_RS12935 (2648220) 2648220..2648537 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NR349_RS12940 (2648558) 2648558..2648887 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
NR349_RS12945 (2649251) 2649251..2653829 - 4579 Protein_2528 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T253583 WP_001094400.1 NZ_CP102380:2648558-2648887 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT253583 WP_000072690.1 NZ_CP102380:2648220-2648537 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
PDB 2EA9
PDB 2JN7
AlphaFold DB P52141

References