Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
| Location | 2637023..2638460 | Replicon | chromosome |
| Accession | NZ_CP102380 | ||
| Organism | Escherichia coli strain BM28 | ||
Toxin (Protein)
| Gene name | rnlA | Uniprot ID | P52129 |
| Locus tag | NR349_RS12860 | Protein ID | WP_000155570.1 |
| Coordinates | 2637023..2638096 (+) | Length | 358 a.a. |
Antitoxin (Protein)
| Gene name | rnlB | Uniprot ID | P52130 |
| Locus tag | NR349_RS12865 | Protein ID | WP_000461704.1 |
| Coordinates | 2638089..2638460 (+) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NR349_RS12845 (2632455) | 2632455..2634644 | - | 2190 | WP_000136402.1 | DEAD/DEAH box helicase | - |
| NR349_RS12850 (2634641) | 2634641..2636257 | - | 1617 | WP_000445380.1 | anti-bacteriophage protein AbpA | - |
| NR349_RS12855 (2636617) | 2636617..2636880 | - | 264 | WP_000502050.1 | DUF1524 domain-containing protein | - |
| NR349_RS12860 (2637023) | 2637023..2638096 | + | 1074 | WP_000155570.1 | type II toxin-antitoxin system toxin mRNA endoribonuclease RnlA | Toxin |
| NR349_RS12865 (2638089) | 2638089..2638460 | + | 372 | WP_000461704.1 | type II toxin-antitoxin system antitoxin RnlB | Antitoxin |
| NR349_RS12870 (2638815) | 2638815..2639678 | + | 864 | WP_000787597.1 | GTPase family protein | - |
| NR349_RS12875 (2639770) | 2639770..2640591 | + | 822 | WP_000197391.1 | DUF932 domain-containing protein | - |
| NR349_RS12880 (2640808) | 2640808..2641509 | + | 702 | WP_000189409.1 | WYL domain-containing protein | - |
| NR349_RS12885 (2641550) | 2641550..2641786 | + | 237 | WP_001144029.1 | protein YpjK | - |
| NR349_RS12890 (2641786) | 2641786..2642229 | + | 444 | WP_000824222.1 | lipoprotein YfjS | - |
| NR349_RS12895 (2642253) | 2642253..2642720 | + | 468 | WP_000702495.1 | protein YfjT | - |
| NR349_RS12900 (2643107) | 2643107..2643259 | - | 153 | Protein_2519 | arsenate reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 358 a.a. Molecular weight: 40061.13 Da Isoelectric Point: 6.8293
>T253582 WP_000155570.1 NZ_CP102380:2637023-2638096 [Escherichia coli]
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
Download Length: 1074 bp
Antitoxin
Download Length: 124 a.a. Molecular weight: 13664.69 Da Isoelectric Point: 4.2391
>AT253582 WP_000461704.1 NZ_CP102380:2638089-2638460 [Escherichia coli]
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
Download Length: 372 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|