Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 4829591..4830072 Replicon chromosome
Accession NC_015635
Organism Microlunatus phosphovorus NM-1

Toxin (Protein)


Gene name relE Uniprot ID F5XTU7
Locus tag MLP_RS21900 Protein ID WP_013865380.1
Coordinates 4829809..4830072 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID F5XTU6
Locus tag MLP_RS21895 Protein ID WP_013865379.1
Coordinates 4829591..4829812 (+) Length 74 a.a.

Genomic Context

MLP_RS21860MLP_RS21865MLP_RS21870MLP_RS21895MLP_RS21900MLP_RS21905MLP_RS21920MLP_RS21875MLP_RS21880MLP_RS21885MLP_RS21890MLP_RS21910MLP_RS21915MLP_RS21925MLP_RS21930
Location: 4825936..4826682 (747 bp)
Type: Others
Protein ID: WP_013865372.1
Location: 4826679..4827512 (834 bp)
Type: Others
Protein ID: WP_013865373.1
Location: 4827466..4827762 (297 bp)
Type: Others
Protein ID: WP_013865374.1
Location: 4829591..4829812 (222 bp)
Type: Antitoxin
Protein ID: WP_013865379.1
Location: 4829809..4830072 (264 bp)
Type: Toxin
Protein ID: WP_013865380.1
Location: 4830107..4830913 (807 bp)
Type: Others
Protein ID: WP_013865381.1
Location: 4832672..4833001 (330 bp)
Type: Others
Protein ID: WP_013865384.1
Location: 4827753..4828106 (354 bp)
Type: Others
Protein ID: WP_013865375.1
Location: 4828103..4828471 (369 bp)
Type: Others
Protein ID: WP_013865376.1
Location: 4828533..4828967 (435 bp)
Type: Others
Protein ID: WP_041793204.1
Location: 4828960..4829364 (405 bp)
Type: Others
Protein ID: WP_083843910.1
Location: 4831226..4832077 (852 bp)
Type: Others
Protein ID: WP_013865382.1
Location: 4832202..4832627 (426 bp)
Type: Others
Protein ID: WP_041790446.1
Location: 4833068..4833595 (528 bp)
Type: Others
Protein ID: WP_013865385.1
Location: 4833592..4834152 (561 bp)
Type: Others
Protein ID: WP_013865386.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MLP_RS218604825936..4826682+747WP_013865372.1hypothetical protein-
MLP_RS218654826679..4827512+834WP_013865373.1hypothetical protein-
MLP_RS218704827466..4827762+297WP_013865374.1hypothetical protein-
MLP_RS218754827753..4828106-354WP_013865375.1TfoX/Sxy family protein-
MLP_RS218804828103..4828471-369WP_013865376.1nuclear transport factor 2 family protein-
MLP_RS218854828533..4828967-435WP_041793204.1SRPBCC domain-containing protein-
MLP_RS218904828960..4829364-405WP_083843910.1metalloregulator ArsR/SmtB family transcription factor-
MLP_RS218954829591..4829812+222WP_013865379.1ribbon-helix-helix protein, CopG familyAntitoxin
MLP_RS219004829809..4830072+264WP_013865380.1type II toxin-antitoxin system RelE/ParE family toxinToxin
MLP_RS219054830107..4830913+807WP_013865381.1aminoglycoside phosphotransferase family protein-
MLP_RS219104831226..4832077-852WP_013865382.1hypothetical protein-
MLP_RS219154832202..4832627-426WP_041790446.1NAD(+)--rifampin ADP-ribosyltransferase-
MLP_RS219204832672..4833001+330WP_013865384.1hypothetical protein-
MLP_RS219254833068..4833595-528WP_013865385.1flavin reductase family protein-
MLP_RS219304833592..4834152-561WP_013865386.1NAD(P)H-dependent oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-85)

Antitoxin

Relaxosome protein TraY

(4-40)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10132.60 Da        Isoelectric Point: 9.9075

>T25358 WP_013865380.1 NC_015635:4829809-4830072 [Microlunatus phosphovorus NM-1]
VTHWHLETSPQFDKTARKLDQQTLHRVRAHLDQVCELEDPRTRGKGLTGKLAGYWRYRIGDYRVIVEIRDHALVIIAITI
GHRSGVY

Download         Length: 264 bp

>T25358 NC_015635:4829809-4830072 [Microlunatus phosphovorus NM-1]
GTGACGCACTGGCATTTGGAGACCTCACCCCAGTTCGACAAAACGGCACGCAAGCTCGACCAACAGACACTGCATCGCGT
CCGGGCCCACCTTGACCAGGTCTGCGAACTCGAAGACCCACGCACTCGCGGCAAAGGACTGACGGGCAAGCTCGCCGGGT
ACTGGCGGTACCGGATCGGTGACTACCGCGTGATCGTGGAGATTCGCGACCACGCCTTGGTCATCATCGCGATCACGATC
GGGCACCGATCCGGTGTCTACTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8559.49 Da        Isoelectric Point: 4.2939

>AT25358 WP_013865379.1 NC_015635:4829591-4829812 [Microlunatus phosphovorus NM-1]
MPLSIRLTEDEEARLTALAERTGRSKTFYVRQAIEAYLEDLEEQYWADEAVREWEASGKRSRPAQQLWDELGV

Download         Length: 222 bp

>AT25358 NC_015635:4829591-4829812 [Microlunatus phosphovorus NM-1]
ATGCCGTTGTCCATTCGGCTGACCGAAGACGAAGAAGCACGTCTGACCGCGCTCGCGGAGCGGACTGGTCGCTCAAAGAC
CTTCTATGTGCGCCAAGCCATCGAGGCCTATCTGGAGGACCTCGAAGAGCAGTACTGGGCTGATGAGGCCGTGCGCGAGT
GGGAGGCCTCGGGCAAGAGATCCCGTCCAGCTCAGCAGTTGTGGGATGAGCTGGGCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBF5XTU7

Antitoxin

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Source
ID
Structure
AlphaFold DBF5XTU6

References