Detailed information of TA system TA025357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 4792513..4793162
• Replicon: chromosome
• Accession: NC_015635
• Organism: Microlunatus phosphovorus NM-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: F5XTQ5
• Locus tag: MLP_RS21700
• Protein ID: WP_013865338.1
• Coordinates: 4792513..4792893 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: F5XTQ6
• Locus tag: MLP_RS21705
• Protein ID: WP_013865339.1
• Coordinates: 4792890..4793162 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MLP_RS21675	4788247..4788630	+	384	WP_013865333.1	hypothetical protein	-
MLP_RS21680	4788627..4789055	+	429	WP_013865334.1	hypothetical protein	-
MLP_RS21685	4789070..4790893	+	1824	WP_013865335.1	hypothetical protein	-
MLP_RS21690	4791144..4791728	-	585	WP_041790432.1	aminoacyl-tRNA hydrolase	-
MLP_RS21695	4791736..4792338	-	603	WP_013865337.1	50S ribosomal protein L25/general stress protein Ctc	-
MLP_RS21700	4792513..4792893	-	381	WP_013865338.1	type II toxin-antitoxin system VapC family toxin	Toxin
MLP_RS21705	4792890..4793162	-	273	WP_013865339.1	ribbon-helix-helix domain-containing protein	Antitoxin
MLP_RS21710	4793380..4794045	-	666	WP_013865340.1	response regulator transcription factor	-
MLP_RS21715	4794042..4795022	-	981	WP_156821472.1	HAMP domain-containing protein	-
MLP_RS21720	4795089..4796375	-	1287	WP_013865342.1	ArsB/NhaD family transporter	-
MLP_RS21725	4796638..4797096	-	459	WP_013865343.1	CBS domain-containing protein	-
MLP_RS21730	4797352..4797996	+	645	WP_041790436.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-106)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-39)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13968.05 Da
• Isoelectric Point: 6.7600

>T25357 WP_013865338.1 NC_015635:c4792893-4792513 [Microlunatus phosphovorus NM-1]
MILVDTDVLIAHLGGVEAARRWLRSARDLAPLHVSVVTIAELIGGMRSSERREVWTLLASLHAEPVTEVIARRAGEFRRN
YARGHSGIGIADYLIAATADYHGADLQTLNVRHFPMFPDLEPPFTL

Nucleotide

• Length: 381 bp

>T25357 NC_015635:c4792893-4792513 [Microlunatus phosphovorus NM-1]
ATGATCCTGGTCGACACGGATGTGCTGATCGCTCACCTGGGAGGGGTCGAGGCGGCACGTCGATGGTTGCGTTCGGCGCG
TGACTTGGCACCGCTGCATGTGAGTGTCGTGACGATCGCCGAACTCATCGGCGGCATGCGTAGCAGTGAGCGTCGCGAGG
TCTGGACACTGCTGGCCTCGTTGCATGCTGAGCCGGTCACCGAAGTGATCGCCCGACGAGCCGGTGAGTTCAGGCGAAAC
TATGCGCGTGGTCATTCCGGGATCGGGATTGCGGACTATCTGATCGCCGCGACCGCGGACTACCACGGTGCTGACCTGCA
GACCCTCAACGTCCGCCACTTCCCGATGTTCCCCGACTTGGAACCGCCCTTCACCCTGTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9910.01 Da
• Isoelectric Point: 4.3501

>AT25357 WP_013865339.1 NC_015635:c4793162-4792890 [Microlunatus phosphovorus NM-1]
MRRTNIYLEDRQTEALDRLAAGEGVSRAEVIRRLLDRALAGNDDRLAEDLAAIDCSFGVLAEFDVPDREAGAREEHLARI
WQVGSAGVDA

Nucleotide

• Length: 273 bp

>AT25357 NC_015635:c4793162-4792890 [Microlunatus phosphovorus NM-1]
ATGCGTCGGACCAATATCTACCTGGAAGACCGTCAGACCGAGGCGCTCGATCGGTTGGCGGCGGGGGAAGGCGTGTCGCG
GGCCGAGGTCATCAGGCGGCTGCTGGACCGGGCGCTTGCCGGGAACGACGACAGGCTTGCGGAGGATCTGGCCGCCATCG
ACTGCTCGTTCGGCGTCTTGGCGGAGTTCGATGTTCCGGATCGTGAGGCAGGCGCGCGCGAGGAGCATCTCGCGCGCATC
TGGCAGGTTGGCTCAGCTGGGGTCGACGCATGA

Structures

Toxin

• AlphaFold DB: F5XTQ5

Antitoxin

• AlphaFold DB: F5XTQ6