Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 366274..366892 | Replicon | chromosome |
Accession | NZ_CP102380 | ||
Organism | Escherichia coli strain BM28 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | NR349_RS01760 | Protein ID | WP_001291435.1 |
Coordinates | 366274..366492 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | NR349_RS01765 | Protein ID | WP_000344800.1 |
Coordinates | 366518..366892 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NR349_RS01725 (361563) | 361563..362135 | + | 573 | WP_000779842.1 | YbaY family lipoprotein | - |
NR349_RS01730 (362166) | 362166..362477 | - | 312 | WP_000409911.1 | MGMT family protein | - |
NR349_RS01740 (362856) | 362856..363209 | + | 354 | WP_000878140.1 | DUF1428 domain-containing protein | - |
NR349_RS01745 (363251) | 363251..364801 | - | 1551 | WP_262515536.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
NR349_RS01750 (364965) | 364965..365435 | - | 471 | WP_000136192.1 | YlaC family protein | - |
NR349_RS01755 (365551) | 365551..366102 | - | 552 | WP_000102564.1 | maltose O-acetyltransferase | - |
NR349_RS01760 (366274) | 366274..366492 | - | 219 | WP_001291435.1 | HHA domain-containing protein | Toxin |
NR349_RS01765 (366518) | 366518..366892 | - | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
NR349_RS01770 (367438) | 367438..370587 | - | 3150 | WP_262515548.1 | efflux RND transporter permease AcrB | - |
NR349_RS01775 (370610) | 370610..371803 | - | 1194 | WP_001295324.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T253563 WP_001291435.1 NZ_CP102380:c366492-366274 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT253563 WP_000344800.1 NZ_CP102380:c366892-366518 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |